动物实验周围神经损伤模型的研究进展

Advances in experimental animal models of peripheral nerve injury

周围神经损伤动物模型的复制方法包括手术器械损伤、物理因素损伤及其他损伤,目前被普遍认可及广泛应用的模型有横断伤、钳夹伤、卡压伤等。动物实验的关键是,根据实验目的及临床研究需求,选择合适的动物模型,并对动物模型进行优化总结。该文通过对周围神经损伤动物实验研究的相关文献进行检索,对现阶段模型复制的研究进展作出综述。

The approaches to establishing animal models of peripheral nerve injury include inducing injuries with surgical instruments,physical factors and other methods.At present,widely accepted and applied models are transection injury,clamping injury and compression injury.The key to animal experiments is to select appropriate animal models and optimize and summarize them according to experimental purposes and clinical research needs.Through searching relevant literature,this review summarizes the advances in animal model establishment currently available for peripheral nerve injury.