新型冠状病毒肺炎疫情期间居家隔离对健康成年人血脂血糖的影响

Analysis of the effect of home quarantine on blood lipid and glucose of healthy adults during the COVID-19 epidemic times based on the data of physical examination

目的分析新型冠状病毒肺炎疫情期间居家隔离对健康成年人血脂和血糖的影响。方法2020年4月7日至5月1日在北京市体检中心进行健康体检的成年人512例,从中筛选出无慢性传染性疾病、年龄≥18岁、接受社区封闭管理或居家隔离时间为2020年1月23日至3月30日,且2018及2019两年同月份均在北京市体检中心体检的体检者作为研究对象,最终87例纳入本研究。使用单因素重复测量方差分析血脂及血糖三年的变化趋势,进一步使用Bonferroni法分析两两体检年份血糖及血脂水平差异。结果87例研究对象中男性36例(41.4%);女性51例(58.6%),年龄(46.3±13.2)岁(范围:24~74岁)。2018—2020年高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、总胆固醇(TC)、空腹血糖(FBG)指标的随时间变化趋势均有统计学意义(均P<0.05),其中男性LDL-C、TC、FBG差异均有统计学意义(均P<0.05),女性HDL-C、LDL-C、TC、FBG差异均有统计学意义(均P<0.05)。2018、2020年的HDL-C水平均显著低于2019年[(1.27±0.29)、(1.30±0.31)比(1.36±0.34)mmol/L],2020年的LDL-C水平均显著高于2018、2019年[(3.11±0.88)比(2.81±0.77)、(2.84±0.71)mmol/L],2020年的TG水平显著高于2019年[(1.54±1.17)比(1.32±0.80)mmol/L],2019、2020年的TC水平均显著高于2018年[(4.88±0.94)、(5.10±0.99)比(4.63±0.90)mmol/L],2019、2020年的FBG水平均显著低于2018年[(5.34±1.17)、(5.44±1.58)比(5.84±1.70)mmol/L](均P<0.05)。男性LDL-C、TC、TG、FBG四项指标总体均值在各年度均高于女性、HDL-C总体均值低于女性;相比2019年,2020年男性LDL-C、TC均显著升高、女性HDL-C显著降低(均P<0.05)。结论新型冠状病毒肺炎疫情期间居家隔离对血脂及血糖产生不良影响。

Objective To analyze the effect of home quarantine on blood glucose and lipids in healthy adults during the COVID-19 epidemic times.Method From April 7,2020 to May 1,2020,512 adults wereexamined in Beijing physical examination center,of which 87 adults aged olderthan 18,received community closed management or home quarantine from January 23,2020 to March 30,2020,and theadultshad physical examination in Beijing physical examination center in the same month of 2018 and 2019 were selected as controls.The change trend of blood glucose and blood lipid acrossthe three years was analyzed by one-way repeated measurement of variance,and the difference of blood lipid and blood glucose between two years of physical examination was further analyzed by Bonferroni method.Datawereanalyzed by gender.Result Among the 87 subjects,36(41.4%)were male and 51(58.6%)were female.The average age was(46.3±13.2)years and ranged from 24 to 74.The difference of high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),triglyceride(TG),total cholesterol(TC)and fasting blood glucose(FBG)among 2018,2019 and 2020 was statistically significant(all P<0.05),while differences in LDL-C,TC and FBG were statistically significant for males(all P<0.05)and HDL-C,LDL-C,TC and FBG were statistically significant for females(all P<0.05).HDL-C in 2018and 2020were significantly lower than that in 2019[(1.27±0.29),(1.30±0.31)vs.(1.36±0.34)mmol/L],LDL-C in 2020was significantly higher than that in 2018and 2019[(3.11±0.88)vs.(2.81±0.77),(2.84±0.71)mmol/L],TG in 2020 was significantly higher than that in 2019[(1.54±1.17)vs.(1.32±0.80)mmol/L],TC in 2019and 2020were significantly higher than that in 2018[(4.88±0.94),(5.10±0.99)vs.(4.63±0.90)mmol/L],and the FBG in 2019and 2020were significantly lower than that in 2018[(5.34±1.17),(5.44±1.58)vs.(5.84±1.70)mmol/L](all P<0.05).The comparative analysis of men and women showed that the means of LDL-C,TG,TC and FBG of men were higher than those of women while the mean of HDL-C was lower than that of women in each year;compared with 2019,the increase of LDL-C and TC of men was obvious while the decrease of HDL-C of women was obvious(all P<0.05)in 2020.Conclusion During the epidemic period of COVID-19,the home quarantine has adverse effects on blood glucose and lipid.