肠道菌群与结直肠癌关系的临床进展

Clinical progress of the relationship between intestinal flora and colorectal cancer

结直肠癌的发病机制尚未明确,与饮食、炎症、遗传等因素密切相关。加深对恶性肿瘤发病认识,对改善患者预后、延长其生存时间起积极促进意义。自代谢组学的发展及应用,使临床对结直肠癌的认识逐渐加深,尤其是肠道微生物,在结直肠癌的发生、发展中具有重要地位,如肠道微生物紊乱则会引起慢性炎症反应、免疫异常等,并为结直肠癌的治疗提供新的思路。本研究简述肠道菌群与结直肠癌发生发展与临床治疗的关系,以期为肿瘤的预防、治疗提供新的途径。

The pathogenesis of colorectal cancer is not yet clear,and it is closely related to factors such as diet,inflammation,and genetics.Deepening the understanding of the incidence of malignant tumors will play positive role in improving the prognosis of patients and prolonging their survival time.Since the development and application of metabolomics,clinical understanding of colorectal cancer has gradually deepened,especially intestinal microbes,which play important role in the occurrence and development of colorectal cancer.For example,intestinal microbial disorders can cause chronic inflammation,immune abnormalities,etc.,and provide new ideas for the treatment of colorectal cancer.This study briefly de-scribes the relationship between the intestinal flora and the occurrence and development of colorectal cancer and clinical treatment,in order to pro-vide a new way for the prevention and treatment of tumors.