新型冠状病毒核酸标准物质现状分析

Research Status of SARS-CoV-2 Nucleic Acid Reference Materials

新型冠状病毒肺炎是由严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的,其传染性高、致病性强,已在全球蔓延。核酸检测技术为新冠病人确诊和治疗提供科学依据,有效推动"早发现、早治疗、早隔离"的疫情防控策略。自新冠疫情爆发以来,我国陆续研制出来各种新型冠状病毒核酸检测试剂,为疫情防控提供了重要支撑,而新型冠状病毒核酸标准物质为核酸检测质量控制提供了有力保障。简单介绍了国内存在的3种不同形式的标准物质的原理和优缺点,列举了国内现有的新型冠状病毒核酸标准物质,对它们的研究现状及面临的挑战进行了阐述,并展望了未来的发展方向,为新冠病毒核酸标准物质的研制和使用提供了参考。

The Coronavirus disease 2019 is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which is highly infectious and pathogenic,and has spread globally.Nucleic acid detection technology provides scientific basis for the diagnosis and treatment of patients,and effectively promotes the epidemic prevention and control strategy of"early detection,early treatment and early isolation".Since the outbreak of the epidemic,China has successively developed various SARS-CoV-2 nucleic acid testing reagents,which provide important support for the prevention and control of the epidemic,and the SARS-CoV-2 nucleic acid reference materials provide a strong guarantee for the quality control of nucleic acid testing.This article briefly introduces the principles,advantages and disadvantages of the three different forms of reference materials in China,lists the existing domestic SARS-CoV-2 nucleic acid reference materials,and explains their research status and challenges,and development direction.It provides a reference for the development and application of the SARS-CoV-2 nucleic acid reference materials.