内镜下静脉曲张套扎术联合普萘洛尔治疗肝硬化伴上消化道出血的效果分析

Analysis on the Effect of Endoscopic Variceal Ligation Combined with Propranolol in the Treatment of Liver Cirrhosis Complicated with Upper Gastrointestinal Bleeding

目的探讨内镜下静脉曲张套扎术(EVL)联合普萘洛尔治疗肝硬化(LC)伴上消化道出血的临床效果。方法83例LC伴上消化道出血患者随机分为两组,对照组采用EVL治疗,观察组采用EVL联合普萘洛尔治疗。比较两组治疗前后的静脉血流量以及再出血、并发症发生率。结果治疗2周后,两组的门静脉血流量、脾静脉血流量均低于治疗前,且观察组显著低于对照组(P<0.05)。观察组的远期再出血发生率为7.32%,并发症发生率为2.44%,均显著低于对照组的23.81%、21.43%(P<0.05)。结论EVL联合普萘洛尔治疗LC伴上消化道出血可有效降低患者的静脉血流量,减少再出血的发生,且安全性较高。

Objective To explore the clinical effect of endoscopic variceal ligation(EVL)combined with propranolol in the treatment of liver cirrhosis(LC)complicated with upper gastrointestinal bleeding.Methods 83 patients with LC complicated with upper gastrointestinal bleeding were randomly divided into two groups.The control group was treated with EVL,and the observation group was treated with EVL combined with propranolol.The venous blood flows before and after treatment,and incidences of rebleeding and complications were compared between the two groups.Results After 2 weeks of treatment,the portal venous blood flow and splenic venous blood flow in both groups were lower than those before treatment,and the observation group was significantly lower than the control group(P<0.05).The incidence of long-term rebleeding and incidence of complications in the observation group were 7.32%and 2.44%respectively,significantly lower than 23.81%and 21.43%in the control group,respectively(P<0.05).Conclusions EVL combined with propranolol in the treatment of LC complicated with upper gastrointestinal bleeding can effectively reduce patients'venous blood flow and reduce the incidence of rebleeding,with high safety.