加味升降散穴位贴敷治疗痰热型原发性高血压临床研究

Therapeutic effect of modified Shengjiang Powder acupoint application for hypertension patients with phlegm-heat syndrome

目的评价加味升降散穴位贴敷治疗痰热型原发性高血压的疗效。方法将符合入选标准的2018年9月-2019年9月石家庄市中医院61例患者采用分层随机分配法分为2组,其中治疗组30例,对照组31例。对照组口服苯磺酸氨氯地平片,治疗组在对照组基础上加用加味升降散穴位贴敷,2组均治疗4周。分别于治疗前后进行中医证候评分,采用动态血压监测仪进行24 h动态血压测定,包括白天平均收缩压(dMSBP)、白天平均舒张压(dMDBP)、夜间平均收缩压(nMSBP)、夜间平均舒张压(nMDBP)、24小时平均收缩压(24 hMSBP)、24小时平均舒张压(24 hMDBP)并进行血压昼夜节律检测。结果治疗后,治疗组nMSBP、24 hMSBP低于对照组(t值分别为-2.331、-1.511,P值分别为0.045、0.033);治疗组血压昼夜节律[(8.87±8.33)%比(6.94±6.12)%,t=1.034]高于对照组(P<0.05);治疗组治疗后眩晕、头痛、头如裹、呕吐痰涎、心烦不安、口苦、失眠评分均低于对照组(P<0.05)。结论加味升降散穴位贴敷可有效降低痰热型原发性高血压患者的血压水平,且对夜间血压的改善尤为明显,从而减少血压波动,改善患者症状。

Objective To evaluate the effect of modified Shengjiang Powder acupoint application on hypertension patients with phlegm-heat syndrome.Methods A total of 61 patients in Shijiazhuang hospital of traditional chinese medicine(TCM)meeting the inclusion criteria from September 2018 to September 2019 were randomly divided into two groups,the treatment group was 30 cases,the control group was 31 cases.The control group was given Amlodipine Besylate Tablets orally,and the treatment group added modified Shengjiang Powder acupoint application,and both groups were treated for 4 weeks.TCM syndrome scores were performed before and after treatment,and 24 h ambulatory blood pressure were measured with an ambulatory blood pressure monitor,including daytime mean systolic blood pressure(dMSBP),daytime mean diastolic blood pressure(dMDBP),night time mean systolic blood pressure(nMSBP),and night time mean diastolic blood pressure(nMDBP),24-hour mean systolic blood pressure(24 hMSBP),24-hour mean diastolic blood pressure(24 hMDSBP)and blood pressure circadian rhythm detection.Results After treatment,the nMSBP and 24 hMSBP in the treatment group were significantly lower than those control group(t values were-2.331,-1.511,P values were 0.045,0.033),the blood pressure circadian rhythm[(8.87±8.33)%vs.(6.94±6.12)%,t=1.034]of the treatment group was significantly higher than those of the control group(P<0.05);mdizziness,headache,head wraps,vomiting,sputum salivation,upset,mouth pain,insomnia scores of the treatment group after treatment were significantly lower than those in the control group(P<0.05).Conclusion The modified Shengjiang Powder acupoint application can reduce the blood pressure level of hypertension patients with phlegm-heat syndrome,especially for the improvement of night blood pressure,and improve the clinical symptoms.