HRCT肺气肿定量分析与COPD患者疾病相关性分析

Analysis of Relationship between Quantitative Analysis of HRCT Emphysema and Severity of COPD Patients

目的探讨HRCT肺气肿定量分析与COPD患者病情严重程度的关系。方法回顾性分析本院2017年3月至2019年6月收治的50例COPD患者的临床资料,观察HRCT检查的影像学表现,计算肺气肿组织占全肺的比例(LAA%),分析LAA%与肺通气功能指标关系及与症状评分、运动耐量相关性。结果LAA%与FEV1%、FEV1/FVC及FEV1%pred呈负相关,其中与FEV1/FVC相关性最强(r=-0.569,P<0.05);LAA%与mMRC评分、CAT评分呈正相关,与6MWT呈负相关。LAA%与mMRC、CAT、6MWT的相关系数分别为0.298、0.195、-0.271(P<0.05)。结论MSCT检查可清楚显示COPD的影像学特点,HRCT肺气肿定量指标与COPD患者的临床症状、肺功能及运动耐量均相关,可有效评估COPD患者的严重程度。

Objective To explore the relationship between quantitative analysis of HRCT emphysema and severity of COPD patients.Methods The clinical data of 50 patients with COPD admitted to our hospital from March 2017 to June 2019 were retrospectively analyzed.The imaging features of HRCT were observed.The proportion of emphysema tissue in the whole lung(LAA%)was calculated.The relationship between LAA%and index of pulmonary ventilation and the correlation between LAA%and symptom score and exercise tolerance were analyzed.Results LAA%was negatively correlated with FEV1%,FEV1/FVC,and FEV1%pred,in which the orrelation between LAA%and FEV1/FVC was the strongest.(r=-0.569,P<0.05).LAA%was positively correlated with mMRC score and CAT score,and negatively correlated with 6MWT.The correlation coefficients of LAA%with mMRC,CAT and 6MWT were 0.298,0.195,and-0.271,respectively(P<0.05).Conclusion MSCT examination can clearly show the imaging features of COPD.The quantitative index of HRCT emphysema is related to the clinical symptoms,lung function and exercise tolerance of patients with COPD,which can effectively evaluate the severity of COPD patients.