福建省散发性肌萎缩侧索硬化症的危险因素分析

Risk Factor Analysis for Sporadic Amyotrophic Lateral Sclerosis Patients from Fujian Province

目的探索福建省散发性肌萎缩侧索硬化症(ALS)发病的相关危险因素。方法以年龄和性别作为入组匹配因素收集ALS患者(病例组)和对照组,采用χ2检验及Logistic回归进行单因素及多因素分析ALS的相关危险因素。结果病例组外伤史明显高于对照组(P<0.001)。多因素分析显示,头部外伤OR值为3.601(95%可信区间为1.279~10.141),与ALS发病密切相关。每天饮茶1~3杯可能降低ALS风险(调整后OR值为0.355,95%可信区间为0.140~0.898)。结论在福建省散发性ALS患者中,外伤史是其独立的危险因素,以头部外伤更为相关。每天饮茶1~3杯可能降低ALS风险。

Objective To explore the risk factors for sporadic ALS patients from Fujian province.Methods An age-and gender-matched case-control study was performed to collect the ALS-related risk factors.The chi-square test and logistic regression were employed for univariate and multivariate analysis.Results The rate of traumatic events in ALS cases was significant higher than that in the controls(P<0.01),and the adjusted OR of head traumatic event was 3.601(95%CI:1.279-10.141).Besides,drinking tea with one to three cups daily seemed to be protective for ALS(OR:0.355;95%CI:0.140-0.898).Conclusion In this cohort of sporadic ALS patients,traumatic event may link to the increase risk for ALS,and tea consumption seems to be a protective factor.