口腔骨组织工程支架中的常用化学交联剂及其应用进展

Chemical crosslinkers commonly used in oral bone tissue engineering scaffolds and their application progress

近年来,骨组织工程为口腔颌面骨组织的大面积缺损提供了修复的可能,支架作为骨组织工程中的重要一环,为细胞附着、增殖及新生骨组织形成提供结构支持。通过交联技术对支架材料进行改性,可提高其机械性能、抗降解性能等,其中化学交联较为常用。该文就口腔骨组织工程中常用化学交联剂的特点及其应用进展作一综述。

In recent years,bone tissue engineering has provided the possibility of repairing large maxillofacial bone defects.As a key point in bone tissue engineering,scaffolds provide structural support for cellular adhesion,proliferation and bone tissue regeneration.Crosslinking technology is often used to modify scaffold materials to improve their mechanical properties and anti-degradation properties,among which chemical crosslinking is more commonly used.In this paper,the characteristics and application of chemical crosslinkers in oral bone tissue engineering are reviewed.