Noncanonical antibody strategy for broad and potent neutralization of influenza virus

Pathogens with high levels of genetic variability,such as HIV-1 and influenza virus,evade the immune system by constantly changing their proteins vulnerable to neutralization by antibodies Consequently,these highly evolvable viruses are notoriously elusive targets for vaccines.In rare cases,infection of humans with HIV-1 or influenza virus results in production of antibodies that can neutralize a very broad spectrum of viral strains.Such antibodies are referred to as broadly neutralizing.