放射性认知功能障碍的机制及治疗研究进展

The research progress of the mechanism and treatment for radiation-induced cognitive dysfunction

放射治疗简称放疗,目前仍是大多数头颈部癌症治疗方案中重要的组成部分。该方法在提高头颈部癌症患者生存率的同时,亦可引起机体学习、记忆、定向等功能的下降,严重者可进展为痴呆,即放射性认知功能障碍(RICD),成为目前影响头部肿瘤放疗患者生活质量的主要因素。RICD起病隐匿,发病机制尚不明确,防治措施匮乏。文中主要就有关RICD发病机制及防治措施的最新研究进展进行综述。

Radiotherapy is still a major part of the program about treating various head and neck cancers.While improving the survival rate of head and neck cancer patients,radiotherapy can cause the decline of learning,memory,orientation and other functions,seriously,even lead to dementia,namely radiation induced cognitive dysfunction(RICD),which has become a critical factor affecting the quality of life for patients.Because of occult onset and unclear pathogenesis,so far there is few effective preventive and therapeutic tools for RICD.In this paper,the latest research progress on the pathogenesis and treatments of RICD is summarized.