血清学及超声指标与妊娠高血压的相关研究

The correlation between serum and ultrasonic indexes in patient with pregnancy-induced hypertension

目的探讨血清激酶、血脂及超声心动图指标与妊娠高血压患者病情严重程度的相关性。方法选取我院妇产科于2018年1月至2020年1月收治的90例妊娠高血压患者为研究对象,依据患者病情严重程度不同分为三组,A组为子痫、重度子痫前期患者,B组为子痫前期患者,C组为正常孕产妇,每组各30例,检测并比较三组的超声心动图各项心脏指标、血清激酶(血清肌酸激酶同工酶、肌酸激酶)以及血脂水平变化。结果超声心动图结果显示,C组的E/A、LVEF、CI及CO均显著高于A组和B组(p<0.05),B组显著高于A组(p<0.05);心脏形态指标,C组的LVESd、LVEDd及IVSTd均显著低于A组和B组(p<0.05),B组显著低于A组(p<0.05);血清激酶指标,C组的CK、CK-MB、LDH及α-HBDH水平均显著低于A和B组(p<0.05);B组的CK、CK-MB、LDH及α-HBDH显著低于A组(p<0.05);血脂水平,C组的TC、TG、HDL-C及APOB水平据显著低于A组和B组患者(p<0.05),C组的HDL-C及APOA1均显著高于A和B组(p<0.05),A组患者的TC、TG、HDL-C及APOB水平均显著高于B组患者(p<0.05),A组患者的HDL-C显著低于B组患者(p<0.05)。结论心室功能、心室内径、血清激酶及血脂水平变化与患者病情严重程度呈现相关性,综合各项指标检测对患者病情发展判定及治疗方案的制定起重要指导价值。

Objective To investigate the correlation between serum kinase,blood lipids and echocardiographic indicators and the severity of pregnancy-induced hypertension.Methods Ninety patients with pregnancy-induced hypertension who were admitted to the Obstetrics and Gynecology Department of our hospital from January 2018 to January 2020 were selected as the research object.They were divided into three groups according to the severity of the patients’disease.Pre-stage patients,group B were pre-eclampsia patients,group C were normal pregnant women,30 cases in each group,each cardiac index,serum kinase(serum creatine kinase isoenzyme,muscle acid kinase)and changes in blood lipid levels.Results In terms of echocardiography,the E/A,LVEF,CI and CO in group C were significantly higher than those in groups A and B(p<0.05),and group B was significantly higher than group A(p<0.05);In terms of aspects,the LVESd,LVEDd and IVSTd of group C were significantly lower than those of groups A and B(p<0.05),and group B was significantly lower than that of group A(p<0.05).In terms of serum kinases,CK,CK of group C-The levels of MB,LDH andα-HBDH were significantly lower than those of groups A and B(p<0.05);the CK,CK-MB,LDH andα-HBDH of group B were significantly lower than that of group A(p<0.05);On the other hand,the levels of TC,TG,HDL-C and APOB in group C were significantly lower than those in groups A and B(p<0.05),and the HDL-C and APOA1 in group C were significantly higher than those in groups A and B(p<0.05),the levels of TC,TG,HDL-C and APOB in group A were significantly higher than those in group B(p<0.05),and the HDL-C in group A was significantly lower than that in group B(p<0.05).Conclusions The changes of ventricular function,ventricular diameter,serum kinase and blood lipid levels are correlated with the severity of the patient’s condition.The comprehensive detection of various indicators plays an important guiding value in the determination of the patient’s disease development and the formulation of treatment plans.