三才封髓丹加味治疗肾虚肝郁型失眠临床研究

Clinical research of modified Sancai Fengsui Dan for insomnia of kidney deficiency and liver depression

目的观察三才封髓丹加味治疗肾虚肝郁型失眠的临床疗效。方法将64例肾虚肝郁型失眠患者按照随机数字表法分为2组,治疗组32例予三才封髓丹加味治疗,对照组32例予艾司唑仑片每晚睡前口服治疗。2组均治疗4周。比较2组疗效;观察2组治疗前后精神分裂症患者生活质量量表(SQLS)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)、匹兹堡睡眠质量指数(PSQI)评分及中医证候评分变化;观察2组不良反应。结果治疗组总有效率93.75%(30/32),对照组总有效率71.88%(23/32),治疗组疗效优于对照组。2组治疗后SQLS、HAMA、HAMD评分,PSQI各项评分及总评分,中医证候各项评分及总评分均较本组治疗前降低(P<0.05),且治疗组降低更明显(P<0.05)。治疗组不良反应发生率9.37%(3/32),对照组不良反应发生率31.25%(10/32)。结论三才封髓丹加味治疗肾虚肝郁证型失眠,能提高患者睡眠质量,改善中医症状及生活质量,疗效优于艾司唑仑片治疗,且毒副作用较低。

ObjectiveTo observe the clinical efficacy of modified Sancai Fengsui Dan for insomnia of kidney deficiency and liver depression.MethodsTotally 64 patients with insomnia of kidney deficiency and liver depression were randomly divided into two groups,32 patients in treatment group were treated with modified Sancai Fengsui Dan,and 32 patients in control group were treated with estazolam tablets every night before going to bed.All patients were treated for 4 weeks.Curative effect,schizophrenia quality of life scale(SQLS),hamilton anxiety scale(HAMA),hamilton depression rating scale(HAMD),pittsburgh sleep quality index(PSQI),traditional Chinese medicine(TCM)syndrome scores as well as adverse reaction between groups were compared before and after treatment.ResultsThe total effective rates in treatment group were better than those in control group[93.75%(30/32)vs 71.88%(23/32),(P<0.05),respectively].Compared with before treatment,SQLS,HAMA,HAMD,PSQI and TCM syndrome scores in groups was lower after treatment(P<0.05),which in treatment group was significantly decreased(P<0.05).The rate of adverse reaction in treatment group were lower than those in control group[9.39%(3/32)vs 31.25%(10/32),(P<0.05),respectively].ConclusionFor patients with insomnia of kidney deficiency and liver depression,modified Sancai Fengsui Dan can improve sleep quality,TCM symptoms and quality-of-life.The curative effect is better than that of estazolam tablets,and the side effects are lower.