清热利湿益肠汤对溃疡性结肠炎患者结肠黏膜病变与炎性因子水平的影响

Effect of Qingre Lishi Yichang Decoction on the colonic mucosal lesions and inflammatory factors in the treatment of ulcerative colitis

目的研究清热利湿益肠汤对溃疡性结肠炎患者结肠黏膜病变及血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)水平的影响。方法选取中国人民解放军联勤保障部队第九二四医院于2018年5月至2019年5月期间接受治疗的82例溃疡性结肠炎患者,依据随机数字表法分为对照组和试验组,各41例。对照组患者接受柳氮磺吡啶治疗,试验组患者在对照组治疗的基础上接受清热利湿益肠汤治疗,60 d为1个疗程,均进行2个疗程的治疗。比较两组患者治疗后的临床疗效,治疗前后结肠黏膜Baron评分、生活质量量表(SF-36)评分及血清IL-6、TNF-α、CRP水平,治疗期间不良反应总发生率。结果治疗后试验组患者临床总有效率为97.56%,显著高于对照组患者的78.05%;治疗后两组患者结肠黏膜Baron评分以及血清IL-6、TNF-α、CRP水平均显著低于治疗前,且试验组显著低于对照组,而两组患者一般健康状况、精神健康、躯体疼痛、社会功能各项生活质量评分均显著高于治疗前,且试验组显著高于对照组(均P<0.05);治疗期间两组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。结论应用清热利湿益肠汤对溃疡性结肠炎实行治疗,可有效改善患者结肠黏膜病理变化与生活质量,降低患者体内炎性因子水平,提高治疗效果,且安全性良好。

Objective To study the effect of Qingre Lishi Yichang Decoction on the colonic mucosal lesions and serum interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)in patients with ulcerative colitis.Methods A total of 82 patients with ulcerative colitis in the 924th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army from May 2018 to May 2019 were selected and divided into the control group and the test group according to the random number table method,each group with 41 cases.Patients in the control group were treated with Sulfasalazine,and patients in the test group were treated with Qingre Lishi Yichang Decoction on the basis of the treatment of the control group,60 days were a course of treatment,and both groups were carried out for 2 courses.Compared the clinical efficacy of the two groups of patients after treatment,and the colonic mucosa Baron score,quality of life scale(SF-36)score and serum IL-6,TNF-α,CRP levels of patients before and after treatment,and the total incidence of adverse reactions during treatment.Results After treatment,the total effective rate in the test group was 97.56%,which was significantly higher than 78.05%in the control group;after treatment,the colonic mucosal Baron score and serum IL-6,TNF-α,and CRP levels of the two groups were significantly lower than before treatment,and the test group was significantly lower than the control group,the scores of general health,mental health,physical pain,and social function of the two groups of patients were significantly higher than before treatment,and the test group was significantly higher than the control group(all P<0.05);comparison of the total incidence of adverse reactions of patients between the two groups during treatment,the difference were not statistically significant(P>0.05).Conclusion Qingre Lishi Yichang Decoction on the colonic mucosal lesions can effectively improve the pathological changes of the colonic mucosa and the quality of life of the patients,reduce the level of inflammatory factors in the patient's body,and improve the therapeutic effect,and the security is good.