加巴喷丁联合卡马西平、托吡酯治疗难治性部分性癫痫患者的效果

Effect of Gabapentin Combined with Carbamazepine and Topiramate on Patients with Refractory Partial Epilepsy

目的探讨加巴喷丁联合卡马西平、托吡酯治疗难治性部分性癫痫患者的临床效果。方法选取平煤神马医疗集团总医院2018年10月至2020年10月收治的112例难治性部分性癫痫患者,按随机数字表法分为对照组和观察组,各56例。对照组接受卡马西平片联合托吡酯片治疗;观察组在对照组的基础上加用加巴喷丁胶囊治疗。两组均于治疗6个月后评估临床疗效、记忆力(CMS)和神经功能缺损(NFDS)情况,记录用药期间患者不良反应发生率。结果观察组发作次数少于对照组(P<0.05);观察组治疗有效率(89.29%)高于对照组(53.57%)(P<0.05);观察组CMS评分高于对照组(P<0.05),NFDS评分低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P<0.05)。结论加巴喷丁联合卡马西平、托吡酯治疗难治性部分性癫痫效果显著,且未增加药物不良反应,值得临床推广。

Objective To explore the clinical effect of gabapentin combined with carbamazepine and topiramate in the treatment of patients with refractory partial epilepsy.Methods A total of 112 patients with refractory partial epilepsy admitted to General Hospital of Pingmei Shenma Group from October 2018 to October 2020 were selected and divided into control group and observation group according to a random number table,with 56 cases in each group.The control group was treated with carbamazepine tablets combined with topiramate tablets,the observation group was treated with gabapentin capsules on the basis of the control group.Both groups were evaluated for clinical efficacy,memory(CMS)and neurological deficit(NFDS)after 6 months of treatment,and the incidence of adverse reactions during the medication period was recorded.Results The number of seizures of the observation group was less than that of the control group(P<0.05),the effective rate of treatment of the observation group(89.29%)was higher than that of the control group(53.57%)(P<0.05).The CMS score of the observation group was higher than that of the control group(P<0.05).The NFDS score was lower than that of the control group(P<0.05),there was no significant difference in the incidence of adverse reactions between the two groups(P<0.05).Conclusion Gabapentin combined with carbamazepine and topiramate are effective in the treatment of refractory partial epilepsy without increasing adverse drug reactions,which is worthy of clinical promotion.