慢性咳嗽寒咳证中医病因病机及物质基础探讨

Discussion on the etiology and pathogenesis of chronic cough of the cold pattern in traditional Chinese medicine as well as its material basis in Western medicine

临床常见寒冷刺激诱发的慢性咳嗽。历代医家强调久咳病因多为瘀、寒、风、虚等,以及内、外寒共同作用导致慢性咳嗽寒咳证。本团队认为寒冷刺激诱发慢性咳嗽寒咳证具有内外合邪、脏腑相关、虚实夹杂的病机特点。瞬时受体电位A1(transient receptor potential ankyrin 1,TRPA1)和瞬时受体电位M8(transient receptor potential melastatin 8,TRPM8)冷感觉通道参与导致机体咳嗽敏感性增高的多个环节,可能是慢性咳嗽寒咳证发病的重要物质基础之一。

Chronic cough induced by cold stimulation is common clinically.TCM physicians of all dynasties have emphasized that the etiology of prolonged cough is mostly stasis,cold,wind,deficiency,as well as coordinated work of internal and external colds.Our research team believes that cold cough induced by cold stimulation is characterized by internally and externally combined pathogens,zang-fu organ relevance,and deficiency-excess complex.Transient receptor potential ankyrin 1(TRPA1)and transient receptor potential melastatin 8(TRPM8)cold sensory channels are involved in many links leading to the increased cough sensitivity,which may be one of the material bases for the pathogenesis of cold cough of chronic cough.