IL-33水平在首发抑郁症患者中的变化及其与认知功能的关系

Changes of IL-33 level in patients with first-episode depression and its relationship with cognitive function

目的:探讨IL-33水平在首发抑郁症患者中的变化及其与认知功能的关系。方法:选取2018年6月~2020年5月的首发抑郁症首次住院病例65例,设定为观察组,并选取同时期健康者65例,设定为对照组,观察两组IL-33水平以及汉密尔顿抑郁量表24项(HAMD-24)、威斯康星卡片分类测验(WCST)与IL-33水平的相关性。结果:观察组IL-33水平显著高于对照组,差异有统计学意义(P<0.05);观察组HAMD评分总分、阻滞因素和IL-33水平保持正相关性,差异有统计学意义(P<0.05);观察组总正确数、完成分类数少于对照组,总错误数、持续错误数、随机错误数多于对照组,差异有统计学意义(P<0.05);观察组WCST因子总错误数、随机错误数和IL-33保持正相关性,差异有统计学意义(P<0.05);总正确数、完成分类数和IL-33具有负相关性,差异有统计学意义(P<0.05)。结论:抑郁症患者IL-33水平发生明显改变,在其疾病发生发病中具有一定作用,有可能是导致认识功能损伤发生的重要因素。

Objective To investigate the changes of IL-33 level in patients with first-episode depression and its relationship with cognitive function.Method 65 first-episode depression inpatients from June 2018 to may 2020 were selected as the observation group,and 65 healthy people in the same period were selected as the control group.The levels of IL-33 and the correlation between Hamilton Depression Scale 24(hamd-24),Wisconsin Card Sorting Test(WCST)and IL-33 levels were observed in the two groups.Results The level of IL-33 in the observation group was significantly higher than that in the control group(P<0.05);the total score of HAMD score,blocking factors and IL-33 level in the observation group remained positive correlation(P<0.05);the total positive confirmation number and the number of completed classification in the observation group were less than those in the control group,and the total number of errors,continuous errors and random errors in the observation group were more than those in the control group(P<0.05);the total errors,random errors and IL-33 of the observation group kept positive correlation(P<0.05).There was a negative correlation between IL-33 and total positive number,complete classification number and IL-33(P<0.05).Conclusion The level of IL-33 in patients with depression is significantly changed,which plays a certain role in the pathogenesis of depression,which may be an important factor leading to cognitive impairment.