促红细胞生成素产生肝细胞受体在肝纤维化、肝癌发病机制中的作用

Role of erythropoietin-producing hepatocyte receptors in the pathogenesis of liver fibrosis and hepatocellular carcinoma

促红细胞生成素产生肝细胞(Eph)受体是受体酪氨酸激酶家族中最大的亚族,参与机体胚胎发育、血管生成、轴突导向等生理过程。近来有研究显示,Eph受体过量表达于肝纤维化及肝癌组织中,并在肝癌的生长、侵袭、转移中发挥重要作用。探讨了Eph受体在肝纤维化及肝细胞癌中的作用机制,提示Eph受体可能是肝纤维化、肝癌发生发展过程中的重要分子。

Erythropoietin-producing hepatocyte(Eph)receptors are the largest subgroup of the receptor tyrosine kinase family and are involved in the physiological processes such as embryonic development,angiogenesis,and axon guidance.Recent studies have shown that Eph receptors are overexpressed in liver fibrosis and hepatocellular carcinoma tissues and play an important role in the growth,invasion,and metastasis of hepatocellular carcinoma.This article explores the mechanism of action of Eph receptors in liver fibrosis and hepatocellular carcinoma and points out that Eph receptors may be important molecules in the development and progression of liver fibrosis and hepatocellular carcinoma.