摘要
癌毒是肿瘤进程中的关键病机,而肿瘤干细胞是肿瘤生长、转移及复发的主要原因。通过比较癌毒与肿瘤干细胞的概念、致病特征与致病机制,发现二者有诸多相似之处。癌毒病机理论符合现代医学对肿瘤干细胞的认识,肿瘤干细胞可能是癌毒病机的重要生物学内容。从中西医角度探讨癌毒与肿瘤干细胞的科学内涵,对进一步揭示肿瘤的致病机制及提高恶性肿瘤的临床治疗效果具有重要的意义。
The cancer toxin is the key pathogenesis during tumor progression,and cancer stem cells(CSCs)are the main cause of tumor growth,metastasis and recurrence.There are many similarities between cancer toxin and CSCs,particularly the concepts,pathogenic characteristics and pathogenic mechanisms.The pathogenesis theory of cancer toxin accords with the understanding of CSCs in modern medicine,and CSCs may belong to important biological content of the pathogenesis of cancer toxin.It is of great significance to explore the scientific connotation of cancer toxin and CSCs from the perspective of traditional Chinese and Western medicine to further reveal the pathogenesis of tumors and improve the clinical therapeutic effect of malignant tumors.
作者
廖勉勉
王志宇
张奉学
王能
LIAO Mianmian;WANG Zhiyu;ZHANG Fengxue;WANG Neng(Research Center of Integrative Medicine,School of Basic Medicines,Guangzhou University of Chinese Medicine,Guangzhou 510006,China;The Second Clinical Medical College,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510006,China;Sun Yat-sen University Cancer Center,Guangzhou 510006,China)
出处
《世界中医药》
CAS
2021年第20期3058-3062,共5页
World Chinese Medicine
基金
国家自然科学基金项目(81873306,81973526)
广东教育厅科研基金项目(2018KZDXM022,A1-2606-19-111-009)
广东省自然科学基金项目(2016A030306025,2017A030310213)
广东省中医药局项目(20211114)
广州市科技计划项目(201904010407)
广东省科技计划项目(2017B030314166)
广东省中医院院内专项(YN2018MJ07)
广州中医药大学“青年英才培养工程”项目(QNYC20190101)。
关键词
肿瘤干细胞
癌毒病机理论
癌毒留结
癌毒自养
癌毒走注
癌毒残留
癌毒交互
Cancer stem cells
Pathogenesis theory of cancer toxin
Connotation of cancer toxin
Autotrophy of cancer toxin
Invasion and metastasis of cancer toxin
Residue of cancer toxin
Cancer-toxin interaction