美沙拉嗪口服联合中药锡类散保留灌肠治疗溃疡性直肠炎患者的效果

Effects of oral Mesalazine combined with traditional Chinese medicine Xilei powder retention enema in the treatment of patients with ulcerative proctitis

目的:观察美沙拉嗪口服联合中药锡类散保留灌肠治疗溃疡性直肠炎患者的效果。方法:选取82例溃疡性直肠炎患者作为研究对象,以随机数字表法分为对照组(n=41)与观察组(n=41)。对照组给予美沙拉嗪口服治疗,观察组在对照组基础上联合中药锡类散保留灌肠治疗,比较两组治疗前后炎性因子[白细胞介素(IL)-6、IL-10、肿瘤坏死因子-α(TNF-α)]水平、中医临床症状评分、疾病活动指数、治疗效果和不良反应发生率。结果:治疗后,观察组IL-6水平、TNF-α水平、腹痛评分、腹泻评分和Mayo指数均低于对照组,IL-10水平高于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为95.12%(39/41),高于对照组的78.05%(32/41),差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:美沙拉嗪口服联合中药锡类散保留灌肠治疗溃疡性直肠炎患者可改善炎性因子水平,降低中医临床症状评分和Mayo指数,提高治疗总有效率,效果优于单纯美沙拉嗪口服治疗。

Objective:To observe effects of oral Mesalazine combined with traditional Chinese medicine Xilei powder retention enema in the treatment of patients with ulcerative proctitis.Methods:82 patients with ulcerative proctitis were selected as the research objects,and were divided into control group(n=41)and observation group(n=41)by using the random number table.The control group was treated with oral Mesalazine,while the observation group was treated with the traditional Chinese medicine Xilei powder retention enema on the basis of that of the control group.The levels of inflammatory factors[interleukin(IL)-6,IL-10,tumor necrosis factor-α(TNF-α)],the TCM clinical symptom score,the disease activity index,the treatment effects,and the occurrence of adverse reactions between the two groups before and after the treatment.Results:After the treatment,the levels of IL-6,TNF-α,abdominal pain score,diarrhea score and Mayo index in the observation group were lower than those in the control group;the IL-10 level was higher than that of the control group;and the differences were statistically significant(P<0.05).The effective rate of treatment in the observation group was 95.12%(39/41),which was higher than 78.05%(32/41)in the control group,and the difference was statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Oral Mesalazine combined with traditional Chinese medicine Xilei powder retention enema in the treatment of the patients with ulcerative proctitis can improve the levels of inflammatory factors,reduce the TCM clinical symptom score and the Mayo index,and improve the effective rate of treatment.Moreover,it is superior to single oral Mesalazine.