百令胶囊辅助治疗糖尿病肾病患者的疗效及对TGF-β1、UACR的影响

Effect of Corbrin Capsule as an adjuvant treatment of diabetic nephropathy and its influence on TGF-β1 and UACR

目的:分析百令胶囊辅助治疗糖尿病肾病患者的疗效及对TGF-β1、UACR的影响。方法:选择医院2018年6月-2020年2月诊治的糖尿病肾病患者67例,根据治疗方案不同分为对照组(n=35)和治疗组(n=32)。对照组患者接受常规治疗,观察组患者接受百令胶囊辅助治疗。比较两组患者临床疗效、血清学指标、腰围、腰臀比和不良反应。结果:观察组患者有效率高于对照组(P<0.05)。各组治疗前后组内比较,TGF-β1、UACR差异比较有统计学意义(P<0.05),TGF-β1较治疗前升高,UACR水平较治疗前下降,而且观察组患者治疗后TGF-β1水平高于对照组(P<0.05),UACR水平低于对照组(P<0.05)。各组治疗前后组内比较,腰围、腰臀比差异比较有统计学意义(P<0.05),腰围、腰臀比均明显增加,且观察组患者的腰围、腰臀比大于对照组(P<0.05)。观察组患者不良反应率稍高于对照组,但差异比较无统计学意义(P>0.05)。结论:百令胶囊辅助治疗糖尿病肾病,能明显提升疗效,改善肾功能,促使患者体重增加,且安全性较好。

Objective:To investigate effect of corbrin capsule as an adjuvant treatment of diabetic nephropathy and its influence on transforming growth factor-β1(TGF-β1)and urine albumin creatine ratio(UACR).Methods:A total of 67 patients with diabetic nephropathy diagnosed and treated in our hospital between June 2018 and February 2020 were enrolled.The subjects were divided into two groups by treatments.The control group(n=35)received routine treatment,while the treatment group(n=32)received Corbrin Capsules.The two groups were compared for the clinical efficacy,serology,waist circumference,waist-to-hip ratio and adverse reactions.Results:The treatment response was higher in the treatment group than that in the control group(P<0.05).Within-group comparison showed that there were significant differences in TGF-β1 and UACR between baseline and after treatment(P<0.05).After treatment,there were an increase in TGF-β1(P<0.05)and a reduction in UACR in the either group(P<0.05),and these improvements were greater in the treatment group compared with the control group(P<0.05).There were remarkable increases in waist circumference and waist-to-hip ratio in either group after treatment(P<0.05),and the increases were greater in the treatment group compared with the control group(P<0.05).The incidence rate of adverse reactions was slightly higher in the treatment group than that in the control group,but the difference was not statistically significant(P>0.05).Conclusion:Corbrin Capsule as an adjuvant treatment for patients with diabetic nephropathy can significantly improve the treatment response and renal function,increase the body weight,and result in a good safety profile.