精神运动康复疗法结合舍曲林治疗抑郁障碍的疗效与安全性研究

Efficacy and safety of psychomotor rehabilitation combined with sertraline in the treatment of depressive disorder

目的:探讨精神运动康复结合舍曲林治疗抑郁障碍的疗效与安全性。方法:将80例抑郁障碍患者按入组的先后顺序分为对照组(舍曲林50~200 mg/d)和研究组(舍曲林50~200 mg/d+精神运动康复治疗)各40例。治疗8周后,对比两组的临床疗效和安全性。结果:两组患者治疗后各时间点的汉密尔顿抑郁量表(Hamilton’s depression scale,HAMD)评分均较治疗前降低,研究组评分低于对照组(P<0.05);研究组最终临床疗效优于对照组(P<0.05)。两组治疗后各时间点不良反应量表(treatment emergent symptom scale,TESS)评分均无明显差异(P>0.05)。结论:精神运动康复结合舍曲林治疗抑郁障碍疗效显著,安全性高。

Objective:To investigate the efficacy and safety of psychomotor rehabilitation combined with sertraline in the treatment of depressive disorder.Methods:Eighty patients with depression were divided into a control group(sertraline 50-200 mg/d)and a study group(sertraline 50-200 mg/d plus psychomotor rehabilitation).Clinical efficacy and safety were compared between the two groups after 8 weeks of treatment.Results:The scores of Hamilton’s depression scale(HAMD)in both groups were lower after treatment than before and furthermore were lower in the study group than the control group(P<0.05),and finally the clinical efficacy was better in the study group than the control group(P<0.05).There was no significant difference in treatment emergent symptom scale scores between the two groups(P>0.05).Conclusion:Psychomotor rehabilitation combined with sertraline is effective and safe in the treatment of depressive disorder.