丁苯酞治疗急性脑血管病患者的效果

Therapeutic Effect of Butylphthalein in the Treatment of Acute Cerebrovascular Disease

目的分析并探究丁苯酞治疗急性脑血管病患者的临床效果及对患者神经功能的影响。方法研究对象为当地某医院2017年8月至2019年2月收治的120例急性脑血管病患者,采用随机数表法将其均分为两组,对照组和观察组各60例。在患者入院后立即实施心脑电图监护,积极给予抗血小板凝聚、脑神经营养等常规治疗,对照组口服药物阿托伐他汀钙片,观察组在对照组治疗基础上服用丁苯酞软胶囊,每次0.2 g,每日3次。疗程为3个月。评估两组的临床疗效,对比两组患者的神经功能恢复情况。结果观察组治疗总有效率显著高于对照组(P<0.05);治疗前,两组美国国立卫生院卒中量表(NIHSS)评分、Barthel指数量表(BI)比较无统计学差异(P>0.05);治疗后,观察组NIHSS评分较同期对照组明显降低,BI指数较对照组提高(P<0.05);治疗后观察组循环内皮祖细胞(EPCs)数量及其迁移能力优于对照组(P<0.05)。结论在常规治疗基础上应用丁苯酞可显著提高急性脑血管疾病患者的临床疗效,促进患者神经功能恢复,提高其自理能力,并有效增加EPCs及其迁移能力。

Objective To analyze and explore the clinical efficacy of butylphthalide in the treatment of acute cerebrovascular disease and its effect on neurological function.Methods A total of 120 patients with acute cerebrovascular disease treated in a local hospital from August 2017 to February 2019 were randomly divided into two groups,60 in the control group and 60 in the observation group.After admission,the patients were immediately monitored by cardio EEG and actively given routine treatment such as antiplatelet coagulation and brain neurotrophic therapy.The control group took atorvastatin calcium tablets orally,and the observation group took butylphthalide soft capsule on the basis of the treatment of the control group,0.2 g/time,3 times/d.The course of treatment was 3 months.The clinical effects of the two groups were evaluated,and the recovery of neurological function was compared and analyzed.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).There was no significant difference in neurological deficit scale(NIHSS)score and Barthel self-care ability index(Bi index)between the two groups before treatment(P>0.05).After treatment,NIHSS score in the observation group was significantly lower than that in the control group,and Bi index was higher than that in the control group(P<0.05).After treatment,the number and migration ability of circulating endothelial progenitor cells(EPCs)in the observation group were better than those in the control group(P<0.05).Conclusion The application of butylphthalide on the basis of routine treatment can significantly improve the clinical efficacy of acute cerebrovascular diseases,promote the recovery of neurological function,improve their self-care ability,and effectively increase EPCs and their migration ability.