基于数据挖掘分析盛丽先治疗小儿遗尿症用药规律

Analysis of Administration Rules of SHENG Lixian Treating Infantile Enuresis Based on Data Mining

目的:分析盛丽先教授治疗小儿遗尿症的组方用药规律。方法:选取盛丽先教授拟定的71首治疗小儿遗尿症的处方,利用Excel、SPSS Modeler 18、IBM SPSS Statistics 25.0、Cytoscape软件,应用频数统计、关联规则分析及聚类分析方法,分析处方中的药物使用频数以及药性、药味、药物归经的使用频数、高频药物用量情况、常用药物组合等,并对全部药物进行复杂网络分析,得出核心处方。结果:71首处方中共含有90味中药,使用频数≥15次的高频药物共20种。药物归经以肺经、脾经、肾经为多,药性以温、平为主,药味以甘、辛居多。8味高频药物的最大剂量为12 g,最小剂量为6 g,常用剂量为9~10 g。按照药物组合出现的频数由高到低排序,前5位分别是益智仁-乌药、益智仁-桑螵蛸、山药-乌药、山药-桑螵蛸、桑螵蛸-乌药。采用组间连接的聚类分析方法,共得到5类药物组合。复杂网络分析结果所得的核心处方则涉及缩泉丸、四君子汤。结论:盛丽先教授治疗小儿遗尿症的拟方以缩泉丸合四君子汤加减为主,临证用药以归肺经、脾经、肾经,性温、平,味甘、辛的药物为多。

Objective:To analyze the administration rules of Professor SHENG Lixian in the treatment of infantile enuresis.Methods:A total of 71 prescriptions for infantile enuresis formulated by Professor SHENG Lixian were selected.Excel,SPSS Modeler 18,IBM SPSS Statistics 25.0 and Cytoscape software were used to analyze the frequency of medicinal use,nature and flavor of medicines,and meridian entry,the dosage of high-frequency medicines and commonly used medicinal combinations in the prescriptions by the methods of frequency statistics,association rules analysis and cluster analysis.Complex network analysis was performed on all medicines to obtain the core prescription.Results:A total of 90 kinds of Chinese medicines were included in the 71 prescriptions,and 20 kinds of high-frequency medicines with the usage frequency of no less than 15 times.Meridian entries of medicines were mainly the lung,spleen and kidney meridians;nature of medicines was mainly warm and neutral;favors of medicines were mainly sweetness and pungency.The maximum dose of eight high-frequency medicines was 12 g,the minimum dose was 6 g,and the commonly used dose was 9 g to 10 g.According to the frequency of medicinal combinations from high to low,the top five were Fructus Alpiniae Oxyphyllae-Radix Linderae,Fructus Alpiniae Oxyphyllae-Oötheca Mantidis,Rhizoma Dioscoreae-Radix Linderae,Rhizoma Dioscoreae-Oötheca Mantidis and Oötheca Mantidis-Radix Linderae.A total of five medicinal combinations were obtained by the cluster analysis method with intergroup connection.The core prescriptions obtained by complex network analysis involve Suoquan pill and Sijunzi tang.Conclusion:Professor SHENG Lixian's prescriptions for infantile enuresis are mainly based on modified Suoquan pills and Sijunzi tang.As for clinical medication,medicines with meridian entries of the lung,spleen and kidney meridians,warm and neutral nature,as well as favors of sweetness and pungency have a high frequency.