小牛血清去蛋白提取物治疗干眼有效性和安全性的系统评价

Efficacy and safety of deproteinized calf blood extractives for dry eye syndrome:a systematic review

目的系统评价小牛血清去蛋白提取物(DCBE)治疗干眼的有效性和安全性。方法计算机检索PubMed、EMbase、The Cochrane Library、CNKI、WanFang Data、CBM和VIP数据库,搜集有关DCBE治疗干眼有效性和安全性的研究,检索时限均为建库至2021年8月31日。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析。结果共纳入59个研究。Meta分析结果显示:DCBE治疗干眼的总有效率优于空白对照[RR=1.20,95%CI(1.12,1.29),P<0.00001]、玻璃酸钠滴眼液[RR=1.22,95%CI(1.16,1.28),P<0.00001]和羟糖甘滴眼液[RR=1.15,95%CI(1.04,1.27),P=0.006]。DCBE的药物不良事件发生率与空白对照、玻璃酸钠滴眼液的差异均无统计学意义。结论现有证据表明,DCBE治疗干眼具有较好的疗效和安全性。受纳入研究数量和质量的限制,上述结论尚待更多高质量研究予以验证。

Objective To systematically review the efficacy and safety of deproteinized calf blood extractives(DCBE)for dry eye syndrome.Methods PubMed,EMbase,The Cochrane Library,CNKI,WanFang Data,CBM and VIP databases were electronically searched to collect studies on efficacy and safety of DCBE for dry eye syndrome from inception to August 31st,2021.Two reviewers independently screened literature,extracted data and assessed the risk of bias of included studies;then,meta-analysis was performed by using RevMan 5.3 software.Results A total of 59 studies were included.The results of meta-analysis showed that:the total effective rate of DCBE for dry eye syndrome was better than that of control(RR=1.20,95%CI 1.12 to 1.29,P<0.00001),sodium hyaluronate eye drops(RR=1.21,95%CI 1.15 to 1.28,P<0.00001),and hydroxyl sugar eye drops(RR=1.15,95%CI 1.04 to 1.27,P=0.006).The incidence of adverse events had no statistical differences between the DCBE and the control or the sodium hyaluronate eye drops.Conclusion Current evidence shows that DCBE for dry eye syndrome can improve the total effective rate,and the safety is acceptable.Due to the limited quality and quantity of the included studies,more high-quality studies are needed to verify the above conclusion.