银杏二萜内酯葡胺注射液联合奥拉西坦治疗脑梗死恢复期对认知功能及血液流变学的影响

Effects of Diterpene Ginkgolides Meglumine Injection Combined with Oxiracetam on Cognitive Function and Hemorheology in Patients with Cerebral Infarction during Recovery Period

目的:探讨银杏二萜内酯葡胺注射液联合奥拉西坦治疗脑梗死恢复期对认知功能及血液流变学的影响。方法:选取2020年1月-2021年1月在葫芦岛市中心医院确诊的脑梗死恢复期患者74例,采用随机分组将患者分为观察组和对照组,每组37例。对照组患者采用奥拉西坦胶囊口服治疗,观察组在对照组基础上加用银杏二萜内酯葡胺注射液治疗。治疗后,评估两组患者临床疗效。分别于治疗前后,采用美国国立卫生研究院卒中量表(NIHSS)评定两组患者神经功能受损程度;采用蒙特利尔认知评估量表(MoCA)评定两组患者认知功能变化情况;采用全自动血液流变检测仪检测两组患者红细胞聚集指数、血小板聚集指数、全血还原黏度、纤维蛋白原及血浆黏度等血液流变学指标;记录两组患者治疗期间不良反应发生情况。结果:治疗后,观察组治疗总有效率为89.19%,高于对照组的67.57%(P<0.05)。治疗后,与对照组相比,观察组NIHSS评分明显降低,MoCA评分明显升高(P<0.05)。治疗后,观察组红细胞聚集指数、血小板聚集指数、全血还原黏度、纤维蛋白原及血浆黏度均低于对照组(P<0.05)。观察组患者不良反应发生率为21.62%,高于对照组的16.22%,但差异无统计学意义(P>0.05)。结论:应用银杏二萜内酯葡胺注射液联合奥拉西坦治疗脑梗死恢复期患者,可有效改善患者神经功能,提高患者认知功能,改变血液流变学指标,避免严重不良反应发生,安全有效。

Objective:To explore the effects of Diterpene Ginkgolides Meglumine Injection combined with Oxiracetam on cognitive function and hemorheology in patients with cerebral infarction during recovery period.Method:A total of 74 patients confirmed with cerebral infarction during recovery period in Huludao Central Hospital were enrolled between January 2020 and January 2021.They were randomly divided into observation group and control group,with 37 cases in each group.The control group was treated with Oxiracetam Capsules orally,observation group was treated with Diterpene Ginkgolides Meglumine Injection on the basis of the control group.After treatment,clinical curative effect in both groups was evaluated.Before and after treatment,neurological impairment in both groups was assessed by national institutes of health stroke scale(NIHSS).The changes of cognitive function in both groups was evaluated by Montreal cognitive assessment scale(MoCA).The hemorheology indexes(erythrocyte aggregation index,platelet aggregation index,whole blood reduced viscosity,fibrinogen,plasma viscosity)in both groups were detected by full-automatic hemorheological detector.The occurrence of adverse reactions during treatment in both groups was recorded.Result:After treatment,the total effective rate in observation group was 89.19%,which was higher than 67.57%in control group(P<0.05).After treatment,compared with control group,NIHSS score was significantly decreased,while MoCA score was significantly increased in observation group(P<0.05).After treatment,the erythrocyte aggregation index,platelet aggregation index,whole blood reducing viscosity,fibrinogen and plasma viscosity in the observation group were lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was 21.62%,higher than 16.22%in the control group,but the difference was not statistically significant(P>0.05).Conclusion:The application of Diterpene Ginkgolides Meglumine Injection combined with Oxiracetam in the treatment of patients with cerebral infarction during recovery period can effectively improve nerve function and cognitive function,change hemorheology indexes,and avoid serious adverse reactions,which is safe and effective.