表皮生长因子联合银离子敷料对III期、IV期压力性损伤患者血清炎性细胞因子和临床疗效的影响

Effect of Epidermal Growth Factor Combined with Silver Ion Dressing on Serum Inflammatory Cytokines and Clinical Efficacy in Patients with Stage III and IV Pressure Injury.

目的探讨分析表皮生长因子联合银离子敷料对III期、IV期压力性损伤患者血清炎性细胞因子和临床疗效的影响。方法选取2019年6月至2021年4月我院收治的压力性损伤患者120例,随机分为观察组和对照组,各60例。对照组患者外用药物为表皮生长因子凝胶,观察组患者外用药物为表皮生长因子凝胶联合银离子敷料。对比分析两组患者治疗前后的血清炎性细胞因子变化情况,观察对比两组患者不同日期点创面炎性反应情况和临床疗效情况。结果治疗1周后和治疗2周后,观察组患者的各项血清炎性细胞因子水平均明显低于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者创面中重度炎症发生率均逐渐降低。治疗1周后、治疗2周后和治疗4周后,观察组患者的中重度炎症发生率均明显低于对照组,差异有统计学意义(=5.673、13.807、4.227,P<0.05)。治疗8周后,观察组患者总有效率为93.33%明显高于对照组总有效率73.33%,差异有统计学意义(=8.641,P<0.05)。结论联合使用重组人表皮细胞生长因子和银离子敷料能够有效降低中重度炎症的发生,降低炎性细胞因子水平,提高临床治疗有效率。

Objective To analyze the impact of epidermal growth factor combined with silver ion dressing on serum inflammatory cytokines and clinical efficacy in patients with stage III and IV pressure injury.Methods A total of 120 patients with pressure injury who came to our hospital for treatment from June 2018 to April 2019 were selected and randomly divided into observation group and control group,with 60 cases in each group.The external medication for patients in the control group was epidermal growth factor gel,and the external medication for patients in the observation group was epidermal growth factor gel combined with silver ion dressing.The changes in serum inflammatory cytokines of the two groups of patients were compared and analyzed,and the inflammatory response and clinical efficacy of the wound at different time points in each group were observed and compared at the same time.Results One week after treatment and two weeks after treatment,the serum inflammatory cytokine levels of the observation group were significantly lower than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the incidence of moderate to severe inflammation in the wounds of the two groups gradually decreased.After 1 week of treatment,2 weeks of treatment,and 4 weeks of treatment,the incidence of moderate to severe inflammation in the observation group was significantly lower than that in the control group,and the differences were statistically significant(=5.673,13.807,4.227,P<0.05).After 8 weeks of treatment,the total effective rate of patients in the observation group was 93.33%,which was significantly higher than the total effective rate of 73.33%in the control group,and the difference was statistically significant(=8.641,P<0.05).Conclusion The combined use of recombinant human epidermal cell growth factor and silver ion dressing can effectively reduce the occurrence of moderate to severe inflammation and the level of inflammatory cytokines,improving the efficiency of clinical treatment.