探讨普瑞巴林治疗带状疱疹后遗神经痛的止痛机制及疗效

The Mechanism and Efficacy of Pregabalin in the Treatment of Postherpetic Neuralgia

目的研究普瑞巴林治疗带状疱疹后遗神经痛的疗效。方法选取2018年9月~2021年9月在某医院确诊的64例带状疱疹后遗神经痛患者。利用随机对照单盲法将64例患者分配到治疗组、对照组。对照组给予普瑞巴林胶囊治疗,治疗组在对照组基础上增加盐酸曲马多缓释片。比较两组愈显率、总有效率;生活质量、VAS疼痛、PSQI评分。结果①治疗组(治愈+显效)率为75.00%、总有效率为96.87%,均高于对照组的50.00%、81.25%,差异有统计学意义(P<0.05)。②两组治疗四周后精神健康、精力、生理机能、生理职能评分、VAS疼痛评分比较,差异有统计学意义(P<0.05)。结论在带状疱疹后遗神经痛的治疗过程中普瑞巴林与盐酸曲马多的联用效果优于普瑞巴林。

OBJECTIVE To study the effect of pregabalin on postherpetic neuralgia.METHODS A total of 64 patients with postherpetic neuralgia diagnosed in a hospital from September 2018 to September 2021 were selected.64 patients were assigned to treatment group and control group by randomized controlled single blind method.The control group was treated with pregabalin capsule,and tramadol hydrochloride sustained-release tablets were added to the treatment group.The callus rate and total effective rate,Quality of life,VAS pain,PSQI score were compared between the two groups.RESULTS①The treatment group(cure+markedly effective)rate was 75.00%,the total effective rate was 96.87%,which was higher than the that of control group(50.00%,81.25%),the difference was statistically significant(P<0.05).②After four weeks of treatment,there were significant differences in mental health,energy,physiological function,physiological function score and VAS pain score between the two groups(P<0.05).CONCLUSION The effect of pregabalin combined with tramadol hydrochloride is better than pregabalin in the treatment of postherpetic neuralgia.