CMTM家族成员在肿瘤细胞中的分子机制及潜在临床价值

Molecular Mechanism and Potential Clinical Value of CMTM Family Members in Tumor Cells

恶性肿瘤已成为危害人类健康的重要杀手,针对肿瘤的研究也成为当今医学界的热点。含有MARVEL跨膜结构域的趋化素样因子基因家族(CKLF-like MARVEL transmembrane domain containing family of genes,CMTM family),原名人类趋化素样因子超家族(chemokine-like factor super family,CKLFSF)是由我国学者首次发现的新的基因家族,有着广泛的生物学功能,与人体免疫、造血和生殖系统以及肿瘤具有密切关系。CMTM家族在多种常见肿瘤中表达失调,能够参与多种与癌症发生发展密切相关的信号通路,与肿瘤细胞生物学行为改变有着密切关系。CMTM家族成员在调控肿瘤细胞生物学功能的信号分子机制中具有重要作用,其能够调控肿瘤细胞的细胞周期与细胞凋亡进程、上皮-间充质转化进程和表皮生长因子受体相关的信号通路,并通过调节程序性死亡受体-配体1与肿瘤免疫微环境密切相关。本文综述了CMTM家族在肿瘤细胞增殖、迁移、侵袭、凋亡等生物过程中的信号分子机制,以及CMTM家族在卵巢癌、乳腺癌、肝癌、胃癌、结直肠癌、胰腺癌等多种常见恶性肿瘤中潜在的临床价值。目前,CMTM家族与肿瘤相关的详尽分子机制尚未完全明确。深入研究CMTM家族在肿瘤中表达、生物学作用以及调控机制将会为肿瘤的诊断、治疗以及预测预后等方面提供新的思路和靶点。

Nowadays,malignant tumor has become an important killer endangering human health,and the research on tumor has become a hot spot in the medical field.The CKLF-like MARVEL transmembrane domain containing family of genes(CMTM family),previously called chemokine-like factor super family(CKLFSF).CMTM family is a novel gene family firstly discovered by Chinese scholars and has a wide range of biological functions,which is closely related to human immune,hematopoietic and reproductive systems as well as tumors.CMTM family is dysregulated in many common tumors,can participate in a variety of signaling pathways closely related to the occurrence and development of cancer,which is closely related to the biological behavior changes of tumor cells.CMTM family members play an important role in the signaling molecular mechanisms that regulate the biological function of tumor cells and are able to regulate the signaling pathways of the tumor cell cycle and apoptosis.Including epithelial-mesenchymal transition process,epidermal growth factor receptor related signaling pathways,and closely related to the tumor immune microenvironment by regulating programmed death receptor-ligand 1.In this paper,we review the signaling molecular mechanisms of CMTM family in the biological processes of tumor cell proliferation,migration,invasion and apoptosis,as well as the potential clinical applications of CMTM family in ovarian cancer,breast cancer,liver cancer,gastric cancer,colorectal cancer,pancreatic cancer and other common malignant tumors.At present,the detailed molecular mechanism of CMTM family related to tumor has not been fully clarified.Further study of the expression,biological role and regulatory mechanism of CMTM family in tumor will provide new ideas and targets for tumor diagnosis,treatment and prognosis prediction.