基于数据挖掘探讨中药治疗高危型人乳头瘤病毒感染的用药规律

Exploration on the medication rules of traditional Chinese medicine in the treatment of high risk human papilloma virus infection based on data mining

目的探究中药治疗高危型人乳头瘤病毒(HR-HPV)感染的用药规律。方法通过中国知网、万方数据库、维普数据库收集治疗HR-HPV感染的有效方剂,检索时间为2000年1月至2021年2月。运用古今医案云平台对处方的中药频数、中药属性(四气、五味、归经)进行统计;使用SPSS Modeler 18.0进行聚类分析、关联规则分析,并构建中药复杂网络,筛选中药核心组合。结果共纳入95首处方,涉及中药152味,其中以补益药、清热药、祛湿药多见,归经以肝经、脾经为主,四气以寒、平居多,五味以甘、苦常见。聚类分析将高频中药分为7组,关联分析筛选出20对药物组合。复杂网络分析发现黄芪、白术、黄柏、薏苡仁、白花蛇舌草、党参、茯苓、甘草等8味药为治疗HR-HPV感染的核心处方。结论HR-HPV感染的中药治疗以“健脾祛湿、清热解毒”为基本原则,辅以养血活血,用药以补益药、清热药、祛湿药为主。

Objective To explore the medication rules of traditional Chinese medicine in the treatment of high risk human papilloma virus(HR-HPV)infection.Methods Effective prescriptions for HR-HPV infection were collected from CNKI,Wanfang and VIP databases,and the retrieval time was from January 2000 to February 2021.The frequency and nature of traditional Chinese medicine(four qi,five flavors,meridian entry)were counted by using cloud platform of ancient and modern medical records;SPSS Modeler 18.0 was used for cluster analysis and association rule analysis,and a complex network of traditional Chinese medicine was build to screen the core combination of traditional Chinese medicine.Results A total of 95 prescriptions were included,involving 152 kinds of traditional Chinese medicine,of which tonifying and replenishing medicine,heat-clearing medicine and dampness-draining medicine were the most common.The main meridian entries were liver and spleen,the four qi was mainly cold and flat,the five flavors were mainly sweet and bitter.High-frequency traditional Chinese medicine were divided into seven groups by cluster analysis,and 20 pairs of drug combinations were screened out by association analysis.Eight drugs which were Astragali Radix,Atractylodis Macrocephalae Rhizoma,Phellodendri Chinensis Cortex,Coicis Semen,Hedyotis,Codonopsis Radix,Poria and Glycyrrhizae Radix et Rhizoma found by complex network were the core prescriptions for the treatment of HR-HPV infection.Conclusion The basic principles of traditional Chinese medicine in the treatment of HR-HPV infection are“invigorating spleen for eliminating dampness,clearing heat and removing toxicity”,and nourishing and promoting blood circulation,and the main drugs are tonifying and replenishing medicine,heat-clearing medicine and dampness-draining medicine.