血清α1-酸性糖蛋白、白介素-6及甲状腺激素水平检测在老年呼吸道感染中的诊断价值

Diagnostic value of serum α1-acidic glycoprotein,interleukin-6 and thyroid hormone levels in elderly patients with respiratory tract infection

目的探讨检测血清α1-酸性糖蛋白(AAG)、白介素-6(IL-6)及甲状腺激素水平在老年呼吸道感染中的诊断价值。方法收集2019年12月至2020年12月在蚌埠医学院附属连云港市第二人民医院老年医学科住院的120例老年患者进行回顾性研究,其中呼吸道感染患者60例作为观察组,非感染性疾病患者60例为对照组。对两组血清AAG、IL-6、游离甲状腺素(FT_(4))、游离三碘甲状腺原氨酸(FT_(3))、促甲状腺激素(TSH)水平进行检测比较;采用受试者工作特征曲线(ROC曲线)分析血清AAG、IL-6、FT_(4)、FT_(3)单项及联合检测对老年呼吸道感染的诊断价值。结果观察组患者血清AAG、IL-6水平均高于对照组,差异有统计学意义(P<0.05),FT_(4)、FT_(3)水平均低于对照组,差异有统计学意义(P<0.05),TSH水平低于对照组,但差异无统计学意义(P>0.05)。ROC曲线分析显示,对老年呼吸道感染诊断效能最高的单项指标为IL-6(AUC=0.913),诊断效能最高的组合为AAG+IL-6+FT_(4)+FT_(3)(AUC=0.957)。结论血清AAG、IL-6、FT_(4)、FT_(3)对老年呼吸道感染均有一定的诊断价值,而AAG+IL-6+FT_(4)+FT_(3)联合检测在老年呼吸道感染诊断具有更高的诊断价值。

Objective To explore diagnostic value of serumα1-acidic glycoprotein(AAG),interleukin-6(IL-6)and thyroid hormone levels in elderly patients with respiratory tract infection.Methods A retrospective study was performed on 120 elderly patients hospitalized in the Lianyungang Second People’s Hospital affiliated to Bengbu Medical College from December 2019 to December 2020.60 elderly patients with respiratory tract infection were selected as the observation group and another 60 patients with noninfectious diseases were selected as the control group.Serum levels of AAG,IL-6,free thyroxine(FT_(4)),free triiodothyronine(FT_(3))and thyroid stimulating hormone(TSH)were compared between the two groups.Receiver operating characteristic curve(ROC)was used to analyze the diagnostic value of AAG,IL-6,FT_(4) and FT_(3) single and combined tests in the elderly with respiratory tract infection.Results The serum AAG and IL-6 levels in observation group were higher than those in control group,the differences were statistically significant(P<0.05);The serum FT_(4) and FT_(3) levels were lower than those in control group,the differences were statistically significant(P<0.05);The serum TSH level was lower than that in control group,but the difference was not statistically significant(P>0.05).ROC curve analysis showed that IL-6(AUC=0.913)was the single index with the highest diagnostic efficacy in the elderly with res piratory tract infection,and the com bination with the highes t diagnostic efficacy was AAG+IL-6+FT_(4)+FT_(3)(AUC=0.957).Conclusion Serum AAG,IL-6,FT_(4) and FT_(3) all have certain diagnostic value in the elderly respiratory tract infection,while the combined detection of AAG+IL-6+FT_(4)+FT_(3) has higher diagnostic value in the elderly respiratory tract in fection.