柴胡与赤芍、醋柴胡与白芍配伍前后药效学比较分析

Comparative Analysis of Pharmacodynamics before and after the Compatibility of Bupleurum and Paeoniae Radix Rubra, Vinegar Bupleurum and Paeoniae Radix Alba

目的比较分析柴胡与赤芍、醋柴胡与白芍配伍前后的药效学效果。方法选择169只小鼠(2020年1月—2021年1月)作为该次分析的比较样本,向其机体注射醋酸让腹腔产生疼痛与炎症表现,对其药物镇痛效果以及抗炎效果展开具体的观察。结果醋酸止痛与腹腔毛细血管通透性的增加。在柴胡剂量是16 g/kg、32 g/kg时,没有观察到显著的镇痛效果与抗炎效果,然而醋柴胡剂量是16 g/kg、32 g/kg时,柴胡醋炙以后能获得显著的镇痛效果。在赤芍剂量是32 g/kg时,动物扭体次数显著性降低,其柴胡与赤芍参考1∶1的比例进行联合煎煮,运用药物剂量在32 g/kg时,没有观察到显著的镇痛效果。当运用16 g/kg剂量进行合煎,其醋柴胡以及白芍参考1∶2比例时,能获得显著性的镇痛效果,在剂量是32 g/kg的时候,获得的镇痛效果不够显著。小鼠的胃排空、小肠推进功能。①柴胡为16 g/kg时,进行给药1次后,对于胃排空以及小肠的推进效果影响差异性小。②柴胡以及赤芍参考1∶1的比例配伍之后,运用16 g/kg的剂量实施新斯的明处死小鼠,其胃肠推进功能没有显著性的影响与变化,然而醋柴胡以及白芍参考1∶2的比例配伍之后,运用16 g/kg的剂量实施新斯的明处死小鼠,其胃肠推进功能产生显著性的抑制效果。结论针对醋柴胡的应用,镇痛以及利胆方面的药效学得到增强;而柴胡与赤芍以及醋柴胡与白芍进行配伍之后,其解痉效果得到增强;柴胡与赤芍参考1∶1的比例予以配伍、醋柴胡与白芍参考1∶2的比例予以配伍,抗炎效果以及镇痛效果没有显著性的协同药效学机制。

Objective To compare and analyze the pharmacodynamic effects before and after the compatibility of Bupleurum and Paeoniae Radix Rubra,and Bupleurum vinegar and Paeoniae Radix Alba.Methods 169 mice(from January 2020 to January 2021) were selected as the comparative samples for this analysis.Injecting acetic acid into the body caused pain and inflammation in the abdominal cavity,and carried out specific observations on the analgesic and anti-inflammatory effects of the drugs.Results Acetic acid relieves pain and increases the permeability of abdominal capillaries.When the doses of Bupleurum were 16 g/kg and 32 g/kg,no significant analgesic and anti-inflammatory effects were observed.However,when the dose of Bupleurum vinegar was 16 g/kg or 32 g/kg,the vinegar of Bupleurum vinegar can obtain a significant analgesic effect.When the dose of Paeoniae Radix Rubra root was 32 g/kg,the number of animal writhing times was significantly reduced.When the ratio of Bupleurum and Paeoniae Radix Rubra root was 1:1,the combined decoction was carried out.When the dose of the drug was 32 g/kg,no observation was observed,with significant analgesic effect.When combined with a dose of 16 g/kg for combined decoction and the ratio of vinegar Bupleurum and Radix Paeoniae Rubra to 1:2,a significant analgesic effect can be obtained.When the dose was 32 g/kg kilogram,the analgesic effect obtained is not significant enough.Gastric emptying and small intestine propulsion function of mice.1.When Bupleurum was 16 g/kg,after one administration,there was little difference in the effect of gastric emptying and small intestine propulsion.2.After the compatibility of Bupleurum and Paeoniae Radix Rubra with reference to the ratio of 1:1,the mice were sacrificed with neostigmine at a dose of 16 g/kg,and the gastrointestinal propulsion function of the mice was not significantly affected or changed.However,after vinegar Bupleurum and Radix Paeoniae Rubra were matched in a ratio of 1:2,the mice were sacrificed with neostigmine at a dose of 16 g/kg.Its gastrointestinal propulsion function produces a significant inhibitory effect.Conclusion For the application of Bupleurum vinegar,the pharmacodynamics of analgesia and choleretics have been enhanced.The antispasmodic effect of Bupleurum and Paeoniae Radix Rubra and vinegar Bupleurum and Paeoniae Radix Alba was enhanced.Bupleurum and Paeoniae Radix Rubra root is compatible with reference to the ratio of 1:1,and Bupleurum vinegar and Paeoniae Radix Alba root is compatible with reference to the ratio of 1:2.There was no significant synergistic pharmacodynamic mechanism for anti-inflammatory and analgesic effects.