前列腺特异性膜抗原PET/MRI在前列腺癌中的应用现状与前景

Prostate Specific Membrane Antigen PET/MRI for the Management of Prostate Cancer:Current Status and Future Directions

前列腺癌(prostate cancer,PCa)是常见的老年男性恶性肿瘤,并是其主要致死原因之一。前列腺特异性膜抗原(prostate specific membrane antigen,PSMA)是一种PCa组织特异性高表达的跨膜蛋白,这使得PSMA成为PCa良好的特异性分子影像靶点。目前,PSMA PET/CT在PCa诊断、分期等方面的价值已被广泛认可。随着PET/MRI逐步进入临床,PSMA PET与MRI两种诊断PCa的重要影像学方法的有机结合成为可能。本文就PSMA PET/MRI在PCa中的应用现状与前景进行阐述,以期为临床诊疗提供借鉴。

Prostate cancer(PCa)is one of the most common malignancies and one major leading cause of mortality from cancers in old men.Due to its specific overexpression in PCa cells,the prostate specific mem⁃brane antigen(PSMA)has become an ideal molecular imaging target for PCa.Currently,the value of PSMA PET/CT in the diagnosis and staging of PCa has been widely accepted.With the clinical application of simulta⁃neous PET/MRI,it enables the possibility of combination of PSMA PET and MRI for the management of PCa.Here we present this review on the current status and future direction of the application of PSMA PET/MRI in the management of PCa.