中药解热作用研究进展

Research progress on antipyretic effect of Chinese medicine

发热是机体受到感染和炎性疾病的标志,持续高热会导致细胞变性,引发多器官功能损伤,严重时会影响大脑神经及组织功能。虽然发热过程常见而又普通,但其病理机制涉及多个信号通路,如核转录因子κB信号通路、Toll样受体4信号通路等。大量研究表明,传统中药复方及其活性组分可以降低血清中炎性因子(TNF-α、IL-1β及IL-6)及下丘脑体温调节介质(PGE_(2)、cAMP),抑制NF-κB信号通路,有效抑制体温病理性升高。本文总结PubMed与中国知网数据库中相关文献,就中药活性成分及复方解热作用进行系统阐述,以期为利用传统中药治疗发热,挖掘新型退烧药物提供理论依据及研究思路。

Fever is a sign of infection and inflammatory diseases in the body.Persistent high fever will lead to cell degeneration,causing multiple organ dysfunction,and seriously affecting brain nerve and tissue function.Although the fever process is common and ordinary,its pathological mechanism involves multiple signaling pathways,such as nuclear transcription factorκB signaling pathway,Toll-like receptor 4 signaling pathway.A large number of studies have shown that traditional Chinese medicine compound and its active components can reduce serum inflammatory factors(TNF-α,IL-1βand IL-6)and hypothalamic thermoregulatory mediators(PGE_(2),cAMP),inhibit NF-κB signaling pathway,and effectively inhibit the pathological increase of body temperature.This paper summarizes the relevant literature in PubMed and CNKI database,and systematically expounds the active components of traditional Chinese medicine and the antipyretic effect of compound prescription,in order to provide theoretical basis and research ideas for the use of traditional Chinese medicine in the treatment of fever and the excavation of new anti-fever drugs.