丙型肝炎病毒感染诱发2型糖尿病的相关研究进展

Research Progress of Type 2 Diabetes Mellitus Induced by Hepatitis C Virus Infection

丙型肝炎病毒(HCV)感染与2型糖尿病(T2DM)之间存在密切关系。HCV感染易诱发T2DM,其发病机制涉及HCV可干扰胰岛素信号转导、引起氧化应激、使肝脏脂肪变性、直接破坏胰岛细胞以及使铁沉积增加等。HCV载量与T2DM的发生发展密切相关,与高病毒载量相比,低病毒载量者空腹血糖水平显著降低,因此应早期抗病毒治疗、防止血糖水平升高。有效抗病毒治疗获得持续病毒学应答后,糖代谢指标短期内显著改善,且降糖药种类及剂量均较治疗前明显减少,T2DM发生率显著降低。因此,深入研究HCV与T2DM的相关性,可为未来丙型病毒性肝炎合并T2DM患者早期抗病毒治疗、降低T2DM的发病率提供重要依据。

There is a close relationship between hepatitis C virus(HCV)infection and type 2 diabetes mellitus(T2DM).HCV infection can easily induce T2DM,and its pathogenesis includes:HCV interferes with insulin signaling,HCV causes oxidative stress,HCV causes liver steatosis,HCV directly destroys islet cells and HCV increases iron deposition.HCV load is related to the occurrence and development of T2DM.The fasting blood glucose level of low viral load is higher than that of high viral load,so early antiviral treatment should be taken to prevent the blood glucose level from rising.After effective antiviral treatment and sustained virological response,the indexes of glucose metabolism improve significantly in a short time,the types and doses of hypoglycemic agents decrease significantly compared with those before treatment,and the incidence of T2DM decreases significantly.Therefore,in-depth study on the correlation between HCV and T2DM can provide an important basis for the early antiviral treatment of patients with hepatitis C complicated with T2DM and reducing the incidence of T2DM.