泮托拉唑钠对胃癌术后患者血浆胃动素、hs-CRP、TNF-α的影响

Effect of Pantoprazole Sodium on Plasma Motilin,hs-CRP and TNF-αin Patients after Gastric Cancer Operation

目的:探讨泮托拉唑钠对胃癌术后患者血浆胃动素、hs-CRP、TNF-α的影响。方法:选择2017年5月—2021年6月在本院诊治的胃癌术后患者84例作为研究对象,根据随机1∶1信封抽签法把患者分为泮托拉唑钠组与奥美拉唑钠组,各42例。奥美拉唑钠组给予奥美拉唑钠治疗,泮托拉唑钠组给予泮托拉唑钠治疗,比较两组治疗效果、并发症发生情况、胃动素、hs-CRP、TNF-α水平变化、括约肌压力变化。结果:泮托拉唑钠组治疗总有效率为97.6%,高于奥美拉唑钠组的85.7%,差异有统计学意义(P<0.05);泮托拉唑钠组并发症发生率为4.8%,低于奥美拉唑钠组的33.3%,差异有统计学意义(P<0.05);两组治疗后血清胃动素水平高于治疗前,血清hs-CRP、TNF-α水平低于治疗前,且泮托拉唑钠组优于奥美拉唑钠组,差异有统计学意义(P<0.05);两组治疗后括约肌压力高于治疗前,且泮托拉唑钠组高于奥美拉唑钠组,差异有统计学意义(P<0.05)。结论:相对于奥美拉唑钠,泮托拉唑钠在胃癌术后患者的应用能提高治疗效果,减少并发症,还可促进胃动素的分泌,抑制hs-CRP、TNF-α的表达,从而改善患者的胃动力。

Objective:To investigate the effect of pantoprazole sodium on plasma motilin,hs-CRP and TNF-αin patients with gastric cancer after operation.Methods:A total of 84 patients with gastric cancer who were treated in our hospital from May 2017 to June 2021 were selected as the research subjects.According to the random 1∶1 envelope drawing method,the patients were divided into pantoprazole sodium group and omeprazole sodium group,42 cases in each group.Omeprazole sodium group was treated with omeprazole sodium,and pantoprazole sodium group was treated with pantoprazole sodium.The therapeutic effect,complications,motilin,hs-CRP,TNF-αlevels and sphincter pressure were compared between the two groups.Results:The total effective rate of pantoprazole sodium group was 97.6%,which was higher than 85.7%of omeprazole sodium group,the difference was statistically significant(P<0.05).The incidence of complications in pantoprazole sodium group was 4.8%,which was lower than 33.3%in omeprazole sodium group,the difference was statistically significant(P<0.05).The serum motilin level in the two groups after treatment was higher than that before treatment,and the serum hs-CRP and TNF-αlevels were lower than those before treatment,and the pantoprazole sodium group was better than that of omeprazole sodium group,the difference was statistically significant(P<0.05).The sphincter pressure of the two groups after treatment was higher than that before treatment,and the pantoprazole sodium group was higher than the omeprazole sodium group,the difference was statistically significant(P<0.05).Conclusion:Compares with omeprazole sodium,the application of pantoprazole sodium in patients with gastric cancer after surgery can improve the therapeutic effect,reduce the occurrence of complications,promote the secretion of motilin,and inhibit hs-CRP and TNF-αThe expression,thereby improving the patient’s gastric motility.