血清分形趋化因子联合结缔组织生长因子对扩张型心肌病的诊断价值及与病情严重程度的关系研究

Study on the diagnostic values of serum fractal chemokine combined with connective tissue growth factor for dilated cardiomyopathy and its relationship with the severity of the disease

目的探讨与研究血清分形趋化因子(chemokine C-C motif,CCL)联合结缔组织生长因子(connective tissue growth factor,CTGF)对扩张型心肌病(Dilated cardiomyopathy,DCM)的诊断价值及与病情严重程度的关系。方法2018年7月~2021年2月选择在院诊治的扩张型心肌病患者78例作为病例组,同期选择在院进行体检的健康志愿者78例作为对照组,检测两组血清CCL、CTGF含量,超声检查患者的病情严重程度并进行相关性分析。结果病例组的左室收缩末容积(left ventricular end systolic volume,LVESV)、左室舒张末容积(Left ventricular end diastolic volume,LVEDV)高于对照组(P<0.05),左室射血分数(left ventricular ejection fraction,LVEF)低于对照组(P<0.05)。病例组的血清分形CCL与CTGF含量都高于对照组(P<0.05)。在病例组中,Pearson分析显示LVESV、LVEDV、LVEF与分形CCL、CTGF都存在相关性(P<0.05);多因素Logistic回归分析显示分形CCL、CTGF为影响患者LVEF的重要因素(P<0.05)。结论扩张型心肌病患者多伴随有血清分形CCL与CTGF的高表达,与患者的病情严重程度存在相关性。

Objective To explore and study the diagnostic values of serum fractal chemokine C-C motif(CCL)combined with connective tissue growth factor(CTGF)for dilated cardiomyopathy(DCM)and the relationship to the severity of the disease degree.Methods From July 2018 to February 2021,78 cases of patients with dilated cardiomyopathy who were diagnosed and treated in this hospital were selected as the case group,and 78 cases of healthy volunteers who underwent physical examination in this hospital were selected as the control group during the same period,and the two groups of serum fractal CCL and CTGF were tested.The severity of the disease degree were determined by ultrasound and given correlation analysis.Results The left ventricular end systolic volume(LVESV)and left ventricular end diastolic volume(LVEDV)of the case group were higher than those of the control group(P<0.05),and the left ventricular ejection fraction(LVEF)were lower than the control group(P<0.05).The serum fractal CCL and CTGF contents of the case group were higher than those of the control group(P<0.05).In the case group,Pearson analysis showed that LVESV,LVEDV,LVEF were correlated with fractal CCL and CTGF(P<0.05);Multivariate logistic regression analysis showed that fractal CCL and CTGF were important factors affected patients'LVEF(P<0.05).Conclusion Patients with dilated cardiomyopathy are mostly accompanied by high expression of serum fractal CCL and CTGF,which are related to the severity of the patient's condition.