糖基化:未来可期的新型疾病标志物

Glycosylation:new era for diseases biomarkers

糖基化是蛋白质翻译后修饰的重要形式之一,糖蛋白的糖链在细胞识别、细胞间信号传递、细胞迁移、增殖及分化中均具有重要作用,唾液酸化、岩藻糖基化及糖链分支程度与肿瘤、自身免疫性疾病等发生发展密切相关,聚糖和异常糖基化糖蛋白为疾病发生发展提供了新型生物标志物和干预靶标,并已经成为临床诊断与治疗的研究热点。

Glycosylation is one of the most important posttranslational modification(PTM)for proteins.Glycans of glycoproteins play pivotal effects in cell recognition,signal transduction,differentiation,proliferation and immigration.The sialylation,fucosylation and degree of branching are intimately related to the development and progression of various malignancies and autoimmune diseases.Both glycans as well as glycoprotein have become the hot targets for disease biomarker exploration and therapeutic interventions.