柴葛解肌汤治疗风热小儿流行性感冒的临床观察

Clinical Efficacy of Chaigejieji Decoction for Influenza Caused by Wind-Heat in Children

目的探讨柴葛解肌汤对风热小儿流行性感冒的临床疗效。方法选取2018年12月—2020年12月期间于南京市江宁中医院儿科治疗的86例风热流行性感冒患儿作为研究对象,按随机数字表法分为对照组和研究组,每组各43例。对照组口服西药磷酸奥司他韦颗粒和小儿氨酚黄那敏颗粒治疗,研究组在对照组的基础上给予柴葛解肌汤治疗。治疗2周后,观察比较两组患儿体温恢复正常时间、症状消失时间、病毒转阴时间,炎症因子[C-反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、白细胞介素-6(Lnterleukin,IL-6)],免疫功能(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))及临床疗效。结果治疗后研究组体温恢复正常时间、症状消失时间、病毒转阴时间明显优于对照组,差异均有统计学意义(P<0.05)。两组患儿治疗后炎症因子CRP、TNF-α、IL-6水平均较治疗前降低,差异有统计学意义(P<0.05);且研究组炎症因子CRP、TNF-α、IL-6水平均较对照组明显降低,差异均有统计学意义(P<0.05)。两组患儿治疗后免疫功能CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均较治疗前升高,CD8^(+)水平均较治疗前降低,差异有统计学意义(P<0.05);且研究组免疫功能CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均较对照组明显升高,CD8^(+)水平均较对照组明显降低,差异均有统计学意义(P<0.05)。治疗后研究组总有效率为95.35%(41/43)明显高于对照组81.40%(35/43),差异有统计学意义(P<0.05)。结论柴葛解肌汤可缩短风热流行性感冒的康复时间,降低患儿的炎症因子水平,提高其免疫功能,从而促进临床疗效。

Objective To study the clinical effect of Chaigejieji Decoction on the influenza caused by wind-heat in children.Methods A total of 86 children with influenza caused by wind-heat treated in Jiangning Hospital of Traditional Chinese Medicine from December 2018 to December 2020 were selected and randomly assigned into a control group and a study group,with 43 cases in each group.The control group was treated withoseltamivir phosphate and pediatric paracetamol granules,and the study group with Chaigejieji Decoction on the basis of the therapy in the control group.The treatment lasted for two weeks.The time of body temperature returning to normal,the time of symptoms disappearing,the time of virus test turning negative,and the clinical efficacy were compared between the two groups after treatment.The inflammatory cytokines[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),and interleukin-6(IL-6)]and the immune function indicators(CD3^(+),CD4^(+),CD8^(+),and CD4^(+)/CD8^(+))were compared between before and after treatment and between the two groups.Results Thecontrol group had longer time of body temperature returning to normal,longer time of symptoms disappearing,and longer time of virus test turning negative than the study group(P<0.05).After treatment,the CRP,TNF-α,and IL-6 levels declined in both groups compared with those before treatment and were lower in the study group than in the control group(P<0.05).After treatment,the CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)levels elevated in both groups compared with those before treatment and were higher in the study group than in the control group;the CD8^(+)level declined in both groups compared with that before treatment andwas lower in the study group than in the control group(P<0.05).The total effective rate of the control group was 81.40%(35/43),which was significantly lower thanthat(95.35%,41/43)of the study group(P<0.05).Conclusion Chaigejieji Decoction can shorten the recovery time,reduce the levels of inflammatory cytokines,and improve immune functions,showing remarkable clinical efficacy for the influenza caused by wind-heat in children.