摘要
The combination of spatial transcriptomics(ST)and single cell RNA sequencing(scRNA-seq)acts as a pivotal component to bridge the pathological phenomes of human tissues with molecular alterations,defining in situ intercellular molecular communications and knowledge on spatiotemporal molecular medicine.The present article overviews the development of ST and aims to evaluate clinical and translational values for understanding molecular pathogenesis and uncovering disease-specific biomarkers.
基金
The work was supported by Operation Funding of Shanghai Institute of Clinical Bioinformatics and Shanghai Engineering and Technology Center for Artificial Intelligence of Lung and Heart Diseases from Zhongshan Hospital,The National Nature Science Foundation of China(81873409)
the CAMS Innovation Fund for Medical Sciences(CIFMS)(22021-I2M-1-061).
