四烯甲萘醌联合碳酸钙D_(3)、骨化三醇治疗骨质疏松症的临床效果及对患者骨代谢指标的影响

Clinical effect of menatetrenone combined with calcium carbonate D_(3) and calcitriol in the treatment of osteoporosis and its influence on bone metabolism indexes of patients

目的探究四烯甲萘醌联合碳酸钙D_(3)、骨化三醇治疗骨质疏松症的临床效果及对患者骨代谢指标的影响。方法选取2019年1月至2020年12月本院收治的100例男性骨质疏松症患者作为研究对象,遵循随机数字表法将其分为参照组(n=50)、研究组(n=50)。参照组给予碳酸钙D_(3)联合骨化三醇治疗,研究组给予四烯甲萘醌联合碳酸钙D_(3)、骨化三醇治疗。比较两组的股骨颈、腰椎L1~4骨密度及骨代谢指标、炎性因子水平、治疗效果、不良反应发生情况。结果治疗后,两组的股骨颈、腰椎L1~4骨密度均增大,且研究组大于参照组,差异具有统计学意义(P<0.05)。治疗后,两组的β-胶原特殊序列(β-CTX)水平均降低,骨钙素(BGP)、骨保护蛋白(OPG)、骨碱性磷酸酶(BALP)水平均升高,且研究组优于参照组,差异具有统计学意义(P<0.05)。治疗后,两组的超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)、白细胞介素-6(IL-6)水平均降低,且研究组低于参照组,差异具有统计学意义(P<0.05)。研究组的治疗总有效率为96.00%,高于参照组的80.00%,差异具有统计学意义(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论四烯甲萘醌联合碳酸钙D_(3)、骨化三醇治疗骨质疏松症的临床效果显著,可改善骨密度、骨代谢指标及炎性因子水平。

Objective To explore the clinical effect of menatetrenone combined with calcium carbonate D_(3)and calcitriol in the treatment of osteoporosis and its influence on bone metabolism indexes of patients.Methods A total of 100 patients with osteoporosis treated in our hospital from January 2019 to December 2020 were selected as the research objects,and the patients were divided into reference group(n=50)and study group(n=50)according to the random number table method.The reference group was treated with calcium carbonate D_(3)combined with calcitriol,and the study group was treated with menatetrenone combined with calcium carbonate D_(3)and calcitriol.The femoral neck and lumbar L1-4 bone mineral density,bone metabolism indexes,inflammatory factors levels,treatment effect and adverse reactions were compared between the two groups.Results After treatment,the femoral neck and lumbar L1-4 bone mineral density in the two groups increased,those in the study group were greater than the reference group,and the differences were statistically significant(P<0.05).After treatment,the level ofβ-collagen specific sequence(β-CTX)in the two groups decreased,the levels of bone gla-containing protein(BGP),osteoprotegerin(OPG)and bone alkaline phosphatase(BALP)increased,those in the study group were better than the reference group,and the differences were statistically significant(P<0.05).After treatment,the levels of high sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-8(IL-8)and interleukin-6(IL-6)in the two groups decreased,those in the study group were lower than the reference group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the study group was 96.00%,which was higher than 80.00%of the reference group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Menatetrenone combined with calcium carbonate D_(3)and calcitriol has a significant clinical effect in the treatment of osteoporosis,which can improve bone mineral density,bone metabolism indexes and inflammatory factors levels.