桑白皮汤加减治疗老年痰热蕴肺型慢性阻塞性肺疾病患者疗效及对免疫功能影响研究

Effect of Sangbaipi decoction on elderly patients with chronic obstructive pulmonary disease of heat-phlegm type and its influence on immune function

目的探讨桑白皮汤加减治疗老年痰热蕴肺型慢性阻塞性肺疾病患者的疗效以及对免疫功能影响。方法选取98例老年痰热蕴肺型慢性阻塞性肺疾病患者,通过便利抽样法分为观察组(n=49)和对照组(n=49)。对照组给予西医治疗,观察组在对照组基础上加用桑白皮汤加减治疗。比较两组临床疗效、免疫功能指标(CD^(4+)、CD^(8+)、CD^(4+)/CD^(8+))、血清炎症因子[降钙素原(PCT)、白细胞计数(WBC)、超敏C反应蛋白(hs-CRP)水平]以及肺功能水平[用力肺活量(FVC)、第1秒用力呼气量(FEVl)、FEV_(1)/FVC]。结果观察组临床总有效率优于对照组(χ^(2)=6.08,P<0.05);治疗后,观察组T淋巴细胞亚群CD^(4+)和CD^(4+)/CD^(8+)明显高于对照组,CD^(8+)低于对照组(t分别=3.25、3.08、2.98,P均<0.05),血清PCT、WBC和hs-CRP水平明显低于对照组(t分别=2.08、2.16、2.17,P均<0.05),FEV_(1)、FVC高于对照组(t分别=2.03、2.05,P均<0.05)。结论对老年痰热蕴肺型慢性阻塞性肺疾病患者实施西医联合桑白皮汤加减治疗效果显著,可有效调节其免疫指标以及炎症因子表达,并改善患者肺功能。

Objective To investigate the curative effect of Sangbaipi decoction on elderly patients with chronic obstructive pulmonary disease of heat-phlegm type and its influence on immune function.Methods The 98 elderly patients with chronic obstructive pulmonary disease of heat-phlegm type were enrolled and divided into obstructive group(n=49)and control group(n=49).The control group was given conventional western medicine treatment,and the observation group was treated with Sangbaipi decoction in addition.The clinical efficacy,immune function indicators(CD^(4+),CD^(8+),CD^(4+)/CD^(8+)),serum inflammatory factors[procalcitonin(PCT),white blood cell(WBC),hyper-sensitive C responsive protein(hs-CRP)levels],and lung function levels[forced vital capacity(FVC),forced expiratory volume in one second(FEVl),FEV_(1)/FVC]between two groups were compared.Results The total clinical efficacy of the observation group was better than that of the control group(χ^(2)=6.08,P<0.05).After treatment,the CD^(4+)and CD^(4+)/CD^(8+)in the observation group were significantly higher than the control group,while the CD^(8+)was lower than that in the control group(t=3.25,3.08,2.98,P<0.05).The serum PCT,WBC,and hs-CRP levels in the observation group were significantly lower than those in the control group after treatment(t=2.08,2.16,2.17,P<0.05).After treatment,FEV_(1) and FVC in the observation group were significantly higher than that in the control group(t=2.03,2.05,P<0.05).Conclusion The western medicine treatment combined with Sangbaipi decoction has remarkable effect on elderly patients with chronic obstructive pul-monary disease of heat-phlegm type,which can effectively regulate the immune index and inflammatory factors and im-prove the lung function.