血浆置换在肾病中的应用进展

Progress in the application of plasma exchange in renal diseases

血浆置换是一种常见的体外循环血液净化疗法,目的是去除血循环中致病的抗原、抗体、免疫复合物或者其他有害的物质,以达到缓解症状和控制疾病过程。如今血浆置换疗法应用广泛,涉及到肾脏、神经、血液、风湿等多个系统疾病,在原发及继发性肾病中也积极发挥作用。本综述总结血浆置换在IgA肾病、局灶节段肾小球硬化、抗肾小球基底膜病、抗中性粒细胞胞浆抗体相关性血管炎、系统性红斑狼疮、血栓性微血管病及多发性骨髓瘤等相关肾病中的应用进展,为临床治疗提供参考。

Plasma exchange is a common extracorporeal blood purification therapy designed for removal of pathogenic antigens,antibodies,immune complexes or other harmful substances from plasma,in order to relieve symptoms and control the disease process.Plasma exchange therapy has been widely used in many systemic diseases,such as kidney,nerve,blood and rheumatism,and also plays a role in primary and secondary nephropathy.This review summarizes the application progress of plasma exchange in IgA nephropathy,focal segmentalized glomerulosclerosis,anti-glomerular basement membrane disease,antineutrophil cytoplasmic antibody-associated vasculitis,systemic lupus erythematosus,thrombotic microangiopathy and multiple myeloma,and provides a reference for the clinical treatment of renal diseases.