经前腔静脉麻醉在巴马小型猪中小手术中的应用

Application of intravenous anesthesia through precava in Bama mini-pigs for medium or minor operations

目的探讨经前腔静脉麻醉在巴马小型猪中小手术中的应用效果。方法选用6月龄普通级巴马小型猪15只,雌性7只,雄性8只,体重(23.17±0.35)kg。予咪达唑仑注射液0.1~0.15 mg/kg肌肉注射10~15 min后,取锁骨上窝入路置入中心静脉导管8~10 cm达巴马小型猪前腔静脉,以便于抽血及给药。丙泊酚中/长链脂肪乳注射液20 mg静脉注射,随后静脉注射20~40 mg/h维持麻醉;舒芬太尼注射液2μg静脉注射进行镇痛。麻醉期间,给予吸氧,监测体温、心电和经皮血氧饱和度。结果15只巴马小型猪均获得可靠的麻醉效果,顺利完成胃镜下胆囊切开术1例,肠镜下阑尾内口冲洗术1例,额颞入路大脑中动脉电凝术1例,左侧颈总动脉结扎+左咽升动脉内空气注射术12例。麻醉期间巴马小型猪无甩耳、摇头等情况,生命体征平稳。直肠温度为38.3~38.9℃,心率76.0~107.0次/min,呼吸13.0~42.0次/min,经皮血氧饱和度95.0%~100.0%。结论创建的经前腔静脉注射丙泊酚中/长链脂肪乳注射液复合舒芬太尼注射液可实现全凭静脉麻醉,为巴马小型猪中小手术提供便利。

Objective To investigate the application effect of intravenous anesthesia through precava in Bama mini-pigs for medium or minor operations.Methods Fifteen 6-month-old conventional Bama mini-pigs were selected,including 7 females and 8 males,with average weight being(23.17±0.35)kg.After intramuscular injection of 0.1-0.15 mg/kg of midazolam injection for 10 to 15 minutes,a central venous catheter was inserted 8-10 cm into the anterior vena cava of the Bama mini-pigs through the supraclavicular fossa approach to facilitate blood drawing and drug administration.Twenty milligrams of propofol medium/long chain fat emulsion injection were intravenously injected,followed by intravenous injection of propofol medium/long chain fat emulsion injection to maintain anesthesia at 20-40 mg/h.Sufentanil injection was administered intravenously at 2μg for analgesia.During anesthesia,the pigs were given oxygen inhalation,and their body temperature,electrocardiogram,and percutaneous oxygen saturation were monitored.Results Reliable anesthetic effects were obtained in the 15 Bama mini-pigs,including 1 case of cholecystotomy under gastroscope,1 case of internal orifice irrigation of appendix under enteroscope,1 case of middle cerebral artery electrocoagulation through frontotemporal approach,and 12 cases of left common carotid artery ligation+left ascending pharyngeal artery air injection.During the anesthesia period,the Bama mini-pigs did not shake their ears and did not shake their heads,and their vital signs were stable.The rectal temperature of the Bama mini-pigs was 38.3-38.9℃;the heart rate was 76.0-107.0 beats/min;the respiration rate was 13.0-42.0 breaths/min,and percutaneous oxygen saturation(SpO_(2))was 95.0%-100.0%.Conclusion The created total-intravenous anesthesia using propofol medium/long chain fat emulsion injection combined with sufentanil injection through precava provides convenience for medium or minor operations in Bama mini-pigs.