胺碘酮治疗急诊冠心病快速心律失常患者的临床疗效分析

Clinical efficacy of emergency application of amiodarone in the treatment of coronary heart disease with tachyarrhythmia

目的 探究胺碘酮治疗急诊冠心病快速心律失常患者的临床疗效,分析胺碘酮在临床治疗中的应用价值。方法 回顾性分析60例急诊冠心病快速心律失常患者的临床资料,其中房颤患者30例,室性心动过速患者30例。所有患者均予以胺碘酮治疗,比较房颤患者与室性心动过速患者的心功能指标,观察不良反应发生情况。结果 治疗后,房颤患者左心室射血分数(52.32±3.26)%、左心室舒张末期内径(54.24±5.71)mm及B型脑钠肽水平(502.37±85.24)pg/ml均优于室性心动过速患者的(48.24±4.32)%、(73.86±6.53)mm及(614.05±121.06)pg/ml,差异均有统计学意义(P<0.05)。60例患者共发生便秘2例(3.33%),低血压0例,房室传导阻滞0例,过敏性肺炎0例,不良反应发生率为3.33%(2/60)。结论 急诊冠心病快速心律失常患者行胺碘酮治疗中,室性心动过速患者的胺碘酮治疗效果不如房颤患者,其不同类型的冠心病快速心律失常患者的药物发挥作用不同,但均可以明显纠正患者的不良心功能,实现病情的有效控制,取得更为理想的临床结局。

Objective To investigate the clinical efficacy of emergency application of amiodarone in the treatment of coronary heart disease with tachyarrhythmia,and analyze the application of amiodarone.Methods The clinical data of 60 emergency patients with coronary heart disease and tachyarrhythmia were retrospectively analyzed.Among them,there were 30 patients with atrial fibrillation and 30 patients with ventricular tachycardia.All patients were treated with amiodarone,the cardiac function indexes of patients with atrial fibrillation and patients with ventricular tachycardia were compared,and the occurrence of adverse reactions was observed.Results After treatment,the left ventricular ejection fraction(52.32±3.26)%,left ventricular end-diastolic diameter(54.24±5.71)mm and B-type brain natriuretic peptide level(502.37±85.24)pg/ml of patients with atrial fibrillation were better than(48.24±4.32)%,(73.86±6.53)mm and(614.05±121.06)pg/ml of patients with ventricular tachycardia,and the differences were statistically significant(P<0.05).A total of 2 cases(3.33%)of constipation,0 case of hypotension,0 case of atrioventricular block,and 0 case of allergic pneumonia occurred in 60 patients,with an incidence of adverse reactions of 3.33%(2/60).Conclusion In emergency coronary heart disease patients with tachyarrhythmia,the effect of amiodarone therapy in patients with ventricular tachycardia is not as good as that in patients with atrial fibrillation,and its drug effect is different in different types of coronary heart disease patients with tachyarrhythmia.However,it can significantly correct the poor cardiac function of patients,achieve effective control of the disease,and achieve a more desirable clinical outcome.