应用静脉滴注阿奇霉素与康妇消炎栓联合方案治疗慢性附件炎效果研究

Study on the effect of combined regimen of intravenous infusion of azithromycin and Kangfuxiaoyan suppository in the treatment of chronic adnexitis

目的研究静脉滴注阿奇霉素与康妇消炎栓联合方案治疗慢性附件炎患者中的效果。方法选取2020年1月~2021年1月胶州市第二人民医院收治的64例慢性附件炎患者作为研究对象,根据随机数表法分为对照组和试验组,各32例。对照组患者应用阿奇霉素静脉滴注,试验组患者应用阿奇霉素静脉滴注与康妇消炎栓联合治疗,比较两组患者治疗前后炎症因子水平、症状改善时间、住院天数、治疗总有效率和不良反应发生率。结果治疗后,试验组患者嗜睡、呕吐、头晕等不良反应发生率显著低于对照组,差异有统计学意义(P<0.05);试验组患者白细胞介素-10、肿瘤坏死因子-ɑ、白细胞介素-6水平均显著低于对照组,白细胞介素-2水平显著高于对照组,差异有统计学意义(P<0.05);试验组患者的白带异常症状、腰骶酸痛症状、小腹坠胀症状改善时间明显短于对照组,住院天数也明显短于对照组,差异有统计学意义(P<0.05);试验组患者治疗总有效率明显高于对照组,差异有统计学意义(P<0.05)。结论对慢性附件炎患者,采取阿奇霉素静脉滴注与康妇消炎栓联合用药,可以抑制炎性反应,有效降低并发症发生风险,并提高临床疗效,值得临床应用。

Objective To evaluate the effi cacy of the combined regimen of intravenous infusion of azithromycin and Kangfu Xiaoyan Suppository in treating patients with chronic adnexitis.Methods A total of 64 patients with chronic adnexitis admitted to Jiaozhou Second People’s Hospital from January 2020 to January 2021 were selected as the research objects,and were divided into control group and experimental group according to random number table method,with 32 cases in each group.Patients in the control group were treated with azithromycin intravenous drip,and patients in the experimental group were treated with azithromycin intravenous drip combined with Kangfu xiaoyan Shuan.The levels of infl ammatory factors,symptom improvement time,hospitalization days,total effective rate and incidence of adverse reactions were compared between the two groups before and after treatment.Results After treatment,the incidence of drowsiness,vomiting,dizziness and other adverse reactions in the experimental group was signifi cantly lower than that in the control group,with statistical signifi cance(P<0.05).The levels of interleukin-10,TUMOR necrosis factor-ɑand interleukin-6 in experimental group were signifi cantly lower than those in control group,while the level of interleukin-2 was signifi cantly higher than that in control group,the differences were statistically significant(P<0.05).The improvement time of abnormal leucorrhea symptoms,lumbosacral soreness symptoms and lower abdominal distension symptoms in the experimental group was signifi cantly shorter than that in the control group,and the length of hospitalization was also signifi cantly shorter than that in the control group,with statistical signifi cance(P<0.05).The total eff ective rate in experimental group was signifi cantly higher than that in control group,and the diff erence was statistically signifi cant(P<0.05).Conclusion For patients with chronic adnexitis,azithromycin intravenous drip combined with Kangfu xiaoyan suppositories can inhibit infl ammatory reaction,eff ectively reduce the risk of complications,and improve the clinical effi cacy,which is worthy of clinical application.