摘要
在全球范围内,肝癌是目前癌症最常见的死亡原因之一,其高复发率和高转移率都是导致患者高死亡率的最终原因,因此需要寻求一种更好的治疗方式,以提高患者的生存质量,延长生存时间。胸腺基质淋巴细胞生成素(TSLP)可作用于肿瘤细胞,并且高表达的TSLP可以诱导肿瘤的发生。辅助性T细胞(Th1、Th2)具有抗肿瘤的作用,但在肝癌患者体内,TSLP水平的升高会导致Th1/Th2失衡,增加肝癌的复发率。本文将阐述TSLP在肝癌中基于Th1/Th2平衡的相关信号通路的机制研究,以提供新的临床治疗思路。
Globally,liver cancer is currently one of the most common causes of death from cancer,and its high recurrence and metastasis rates are the ultimate cause of high mortality in patients,hence the need to seek a better treatment to improve the quality and prolong the survival time of patients.Thymic stromal lymphopoietin(TSLP)acts on tumour cells and high expression of TSLP can induce tumourigenesis.Helper T cells(Th1 and Th2)have anti-tumour effects,but in liver cancer patients,elevated TSLP levels can lead to Th1/Th2 imbalance and increase the recurrence rate of liver cancer.In this paper,we will describe the mechanistic study of TSLP in liver cancer based on the related signaling pathway of Th1/Th2 balance in order to provide new clinical treatment ideas.
作者
袁梦
刘敏
YUAN Meng;LIU Min(Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine,Suzhou 215000,China)
出处
《河南医学研究》
CAS
2022年第15期2874-2877,共4页
Henan Medical Research
