中枢神经系统感染继发癫痫患者的临床治疗

Clinical treatment of secondary epilepsy in patients with central nervous system infection

目的研究中枢神经系统感染患者继发癫痫的有效治疗方案。方法随机选取解放军总医院第二医学中心神经内科2020-06—2021-01收治的中枢神经系统感染继发癫痫患者中56例为研究对象,随机分为观察组(氟桂利嗪抗菌药+手术治疗)28例与对照组(氟桂利嗪抗菌药单药治疗)28例,比较2组患者治疗的总有效率、不良反应发生率及血清炎性因子。结果观察组总有效率为96.43%,不良反应发生率7.14%,IL-2(4.39±0.66)μg/L,TNF-ɑ(1.58±0.33)μg/L;对照组治疗总有效率为67.85%,不良反应发生率28.56%,IL-2(5.64±0.81)μg/L,TNF-ɑ(2.55±0.35)μg/L,2组比较差异均有统计学意义(P<0.05)。结论氟桂利嗪抗菌药物联合手术治疗中枢神经系统感染继发癫痫的临床效果显著,且不良反应发生率低,有利于控制临床指标。

Objective To study the effective treatment of epilepsy secondary to central nervous system in⁃fection.Methods Fifty-six patients with secondary epilepsy were selected from the patients with central nervous system infection treated in the Department of Neurology,the Second Medical Center of PLA General Hospital from June 2020 to January 2021.They were randomly divided into 28 cases in the observation group(Flunarizine anti⁃biotic+surgical treatment)and 28 cases in the control group(Flunarizine antibiotic).The total effective rate,ad⁃verse events rate and serum inflammatory factor indexes of the two groups were compared.Results In the observa⁃tion group,the total effective rate was 96.43%,the adverse events rate was 7.14%,IL-2 was(4.39±0.66)μg/L,TNF-ɑwas(1.58±0.33)μg/L.In the control group,the total effective rate was 67.85%,the adverse events rate was 28.56%,IL-2 was(5.64±0.81)μg/L,TNF-ɑwas(2.55±0.35)μg/L.The data comparison between the two groups was statistically significant(P<0.05).Conclusion The combined use of flunarizine and surgical therapy is effective in the treatment of epilepsy secondary to central nervous system infection,and the incidence of adverse events is low,which is beneficial to control clinical indicators.