干燥综合征证候研究中的关键问题及应对策略

Key issues and coping strategies in the syndrome study of Sjogren’s syndrome

干燥综合征是风湿免疫科疑难病种,中医药在该疾病治疗上存在独特优势。证候研究在干燥综合征中医药研究中处于核心地位,辨“证”方能施治。但目前存在证候命名不规范、证候规律的研究滞后、证候生物标志物缺失、病证结合动物模型缺失等问题。针对上述问题,笔者指出规范证候名称、进行多中心聚合交叉研究、探索相应的动物模型和生物标志物等具体应对策略。笔者旨在通过对干燥综合征这一疑难病种的关键环节“证”进行深入探索,同时在宏观和微观两个层次进行把握,促使其内涵进行深刻的现代化阐释,以飧同道。

Sjogren’s syndrome is a difficult disease in rheumatology.Traditional Chinese medicine has unique advantages in the treatment of this disease.Syndrome research is at the core of Sjogren’s syndrome research in traditional Chinese medicine.Only by distinguishing ‘syndrome’ can we treat it.At present,however,there are some problems,such as nonstandard naming of syndromes,lagging research on syndrome laws,lack of syndrome bio markers,and lack of animal models for diseasesyndrome combining.In response to the above problems,the author pointed out specific coping strategies such as standardizing syndrome names,conducting multi-center aggregation and cross-research,and exploring corresponding animal models and biomarkers.The author aims to conduct in-depth exploration of ‘syndrome’,the key link of Sjogren’s syndrome,a difficult disease,and to grasp it at the macro and micro levels,so as to promote a profound modern interpretation of its connotation,so as to share the same path.