肠道菌群与胰腺癌诊疗及发病机制的研究进展

Research progress on gut microbiota and diagnosis,treatment and pathogenesis of pancreatic cancer

胰腺癌是恶性程度极高的消化系统肿瘤,发病率逐年上升,严重影响人类身体健康。早期诊断困难、发病机制未明确、治疗效果极差是胰腺癌死亡率高的主要原因。肠道菌群是人体内最多最复杂的细菌群落,其对调节人体免疫系统及保护胃肠道功能有重要作用,但已有大量研究表明肠道菌群功能失调与胰腺癌的发生密切相关。就此,我们对肠道菌群与胰腺癌诊疗及发病机制的研究进展进行分析及归纳,为治疗胰腺癌提供优质方案。

Pancreatic cancer is a highly malignant digestive system tumor,and its incidence is gradually increasing year by year,which seriously affects human health.Difficulties in early diagnosis,unclear mechanisms and poor therapeutic effect are the main reasons for the high mortality of pancreatic cancer.Gut microbiota is the most complex bacterial community in human body,which plays an important role in regulating human immune system and protecting gastrointestinal function.However,a large number of studies have shown that gut microbiota dysfunction is closely related to the occurrence of pancreatic cancer.In this regard,we analyzed and summarized the research progress of gut microbiota and diagnosis,treatment and mechanisms of pancreatic cancer,so as to provide a high-quality program for the treatment of pancreatic cancer.